sulfuric acid

1: 23.3 g / H2O / acetic acid; trifluoroacetic acid / 2.5 h / 75 °C 2: 65 percent / KCH2SOCH3 / dimethylsulfoxide / 1.) 12 deg C, 1 h, 2.) 12 deg C -< RT, 1 h View Scheme

1: aq. H2SO4 2: (i) NaH, (ii) 1-(2-hydrazino-2-oxoethyl)pyridinium chloride, AcOH 3: NH2NH2*H2O, KOH View Scheme

1: 23.3 g / H2O / acetic acid; trifluoroacetic acid / 2.5 h / 75 °C 2: 65 percent / KCH2SOCH3 / dimethylsulfoxide / 1.) 12 deg C, 1 h, 2.) 12 deg C -< RT, 1 h 3: toluene / 5 h / 0 °C 4: 1.26 g / K2CO3 / CH2Cl2 / 2 h / -78 °C 5: 1) m-chloroperbenzoic acid, 2.) diisopropylamine / 1.) -78 deg C, 30 min, 2.) -78 deg C -> RT View Scheme