4-吡唑硼酸频哪醇酯合成路线

参考文献

Journal of Medicinal Chemistry, , vol. 52, # 24 p. 7934 - 7937

269410-08-44-吡唑硼酸频哪醇酯+

78-77-3溴代异丁烷

827614-66-41-异丁基-4-(4,4,5,5-四甲基-1,3,2-二氧硼烷-2-基-1H-吡唑

参考文献

Journal of Medicinal Chemistry, , vol. 52, # 24 p. 7934 - 7937

269410-08-44-吡唑硼酸频哪醇酯+

141699-59-41-Boc-4-甲烷磺酰氧基哌啶

877399-74-14-[4-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)-1H-吡唑-1-基]哌啶-1-甲酸叔丁酯

参考文献

OSI PHARMACEUTICALS, LLC; HOMBERGER, Keith, R.; BERGER, Dan, M.; CHEN, Xin; CREW, Andrew, P.; DONG, Hanqing; KLEINBERG, Andrew; LI, An-Hu; MA, Lifu; MULVIHILL, Mark, J.; PANICKER, Bijoy; SIU, Kam, W.; STEINIG, Arno, G.; TARRANT, James, G.; WANG, Jing; WENG, Qinghua; SANGEM, Rajaram; GUPTA, Ramesh, C.
Patent: WO2011/100502 A1, 2011 ;
Location in patent: Page/Page column 37 ;
WO 2011/100502 A1

269410-08-44-吡唑硼酸频哪醇酯+

75-03-6碘乙烷

847818-70-61-乙基吡唑-4-硼酸频哪醇酯

参考文献

EP1798229 A1, ;

Page/Page column 130 ;

269410-08-44-吡唑硼酸频哪醇酯+

74-96-4溴乙烷

847818-70-61-乙基吡唑-4-硼酸频哪醇酯

参考文献

WO2011/79804 A1, ;

Page/Page column 41 ;
WO 2011/079804 A1

75-30-92-碘代丙烷+

269410-08-44-吡唑硼酸频哪醇酯

879487-10-21-异丙基-4-(4,4,5,5-四甲基-1,3,2-二氧杂戊硼烷-2-基)-1H-吡唑

参考文献

Cui, J. Jean; Tran-Dube, Michelle; Shen, Hong; Nambu, Mitchell; Kung, Pei-Pei; Pairish, Mason; Jia, Lei; Meng, Jerry; Funk, Lee; Botrous, Iriny; McTigue, Michele; Grodsky, Neil; Ryan, Kevin; Padrique, Ellen; Alton, Gordon; Timofeevski, Sergei; Yamazaki, Shinji; Li, Qiuhua; Zou, Helen; Christensen, James; Mroczkowski, Barbara; Bender, Steve; Kania, Robert S.; Edwards, Martin P.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6342 - 6363

269410-08-44-吡唑硼酸频哪醇酯+

75-26-32-溴丙烷

879487-10-21-异丙基-4-(4,4,5,5-四甲基-1,3,2-二氧杂戊硼烷-2-基)-1H-吡唑

参考文献

INCYTE CORPORATION; ZHANG, Colin; QIAN, Ding-quan; ZHUO, Jincong; YAO, Wenqing
Patent: WO2010/75270 A1, 2010 ;
Location in patent: Page/Page column 160-161 ;
WO 2010/075270 A1

10445-91-74-氯甲基吡啶+

269410-08-44-吡唑硼酸频哪醇酯

864754-20-14-[4-(4,4,5,5-四甲基-[1,3,2]二噁硼烷-2-基)-吡唑-1-甲基]-吡啶

参考文献

WO2006/20879 A1, ;

Page/Page column 109 ;
WO 2006/020879 A1

269410-08-44-吡唑硼酸频哪醇酯+

6482-24-22-溴乙基甲基醚

847818-71-71-(2-甲氧基乙基)-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑

参考文献

WO2011/51342 A1, ;

Page/Page column 95 ;
WO 2011/051342 A1

269410-08-44-吡唑硼酸频哪醇酯+

627-42-92-氯乙基甲基醚