4-吡唑硼酸频哪醇酯合成路线

参考文献

F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BHAGIRATH, Niala; DOMINIQUE, Romyr; KENNEDY-SMITH, Joshua; LOPEZ-TAPIA, Francisco Javier; MERTZ, Eric; QIAO, Qi; SO, Sung-Sau
Patent: WO2014/64131 A2, 2014 ;
Location in patent: Page/Page column 128 ;

269410-08-44-吡唑硼酸频哪醇酯+

4584-46-7二甲氨基氯乙烷盐酸

76-09-5频哪醇+

877149-80-9N,N-二甲基-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑-1-乙胺

参考文献

MERCK PATENT GESELLSCHAFT
Patent: US2011/218198 A1, 2011 ;
Location in patent: Page/Page column 15-16 ;

269410-08-44-吡唑硼酸频哪醇酯

877149-80-9N,N-二甲基-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑-1-乙胺

参考文献

INCYTE CORPORATION; Li, Yun-Long; Yao, Wenqing; Combs, Andrew P.; Yue, Eddy W.; Mei, Song; Zhu, Wenyu; Glenn, Joseph; Maduskuie, JR., Thomas P.; Sparks, Richard B.; Douty, Brent
Patent: US2013/59835 A1, 2013 ;

269410-08-44-吡唑硼酸频哪醇酯+

141699-58-31-(叔丁氧基羰基)-3-(甲烷磺酰氧基)氮杂丁烷

877399-35-4

参考文献

Cui, J. Jean; Tran-Dube, Michelle; Shen, Hong; Nambu, Mitchell; Kung, Pei-Pei; Pairish, Mason; Jia, Lei; Meng, Jerry; Funk, Lee; Botrous, Iriny; McTigue, Michele; Grodsky, Neil; Ryan, Kevin; Padrique, Ellen; Alton, Gordon; Timofeevski, Sergei; Yamazaki, Shinji; Li, Qiuhua; Zou, Helen; Christensen, James; Mroczkowski, Barbara; Bender, Steve; Kania, Robert S.; Edwards, Martin P.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6342 - 6363

269410-08-44-吡唑硼酸频哪醇酯+

5407-04-5N,N-二甲氨基氯丙烷盐酸盐

847818-72-8N,N-二甲基-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑-1-丙胺

参考文献

Katz, Jason D.; Jewell, James P.; Guerin, David J.; Lim, Jongwon; Dinsmore, Christopher J.; Deshmukh, Sujal V.; Pan, Bo-Sheng; Marshall, C. Gary; Lu, Wei; Altman, Michael D.; Dahlberg, William K.; Davis, Lenora; Falcone, Danielle; Gabarda, Ana E.; Hang, Gaozhen; Hatch, Harold; Holmes, Rachael; Kunii, Kaiko; Lumb, Kevin J.; Lutterbach, Bart; Mathvink, Robert; Nazef, Naim; Patel, Sangita B.; Qu, Xianlu; Reilly, John F.; Rickert, Keith W.; Rosenstein, Craig; Soisson, Stephen M.; Spencer, Kerrie B.; Szewczak, Alexander A.; Walker, Deborah; Wang, Wenxian; Young, Jonathan; Zeng, Qinwen
Journal of Medicinal Chemistry, 2011 , vol. 54, # 12 p. 4092 - 4108

269410-08-44-吡唑硼酸频哪醇酯+

109-54-6N,N-二甲基-3-氯丙胺

847818-72-8N,N-二甲基-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑-1-丙胺

参考文献

Perry, Benjamin; Beevers, Rebekah; Bennett, Gavin; Buckley, George; Crabbe, Tom; Gowers, Lewis; James, Lynwen; Jenkins, Kerry; Lock, Chris; Sabin, Verity; Wright, Sara
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5299 - 5302

269410-08-44-吡唑硼酸频哪醇酯+

76513-69-42-(三甲基硅烷基)乙氧甲基氯

894807-98-84-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1-([2-(三甲基甲硅烷基)乙氧基]甲基)-1H-吡唑

参考文献

SCHERING CORPORATION; TSUI, Hon-Chung; PALIWAL, Sunil; KIM, Hyunjin, M.; KEREKES, Angela, D.; CAPLEN, Mary Ann; ESPOSITE, Sara, J.; MCKITTRICK, Brian, A.; FISCHMANN, Thierry Olivier; DOLL, Ronald, J.; RAINKA, Matthew Paul; LI, Ang
Patent: WO2011/149874 A2, 2011 ;
Location in patent: Page/Page column 81-82 ;

269410-08-44-吡唑硼酸频哪醇酯+

919291-24-0

919291-27-3

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Garbaccio, Robert M.; Huang, Shaei; Tasber, Edward S.; Fraley, Mark E.; Yan, Youwei; Munshi, Sanjeev; Ikuta, Mari; Kuo, Lawrence; Kreatsoulas, Constanine; Stirdivant, Steve; Drakas, Bob; Rickert, Keith; Walsh, Eileen S.; Hamilton, Kelly A.; Buser, Carolyn A.; Hardwick, James; Mao, Xianzhi; Beck, Stephen C.; Abrams, Marc T.; Tao, Weikang; Lobell, Rob; Sepp-Lorenzino, Laura; Hartman, George D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6280 - 6285

269410-08-44-吡唑硼酸频哪醇酯+

22115-41-92-氰基溴苄

930596-18-2

参考文献

Schering Corporation
Patent: US2007/82900 A1, 2007 ;
Location in patent: Page/Page column 142 ;
US 20070082900 A1

269410-08-44-吡唑硼酸频哪醇酯+

79-44-7二甲氨基甲酰氯

942070-94-2

参考文献

Zhang, Dengyou; Zhang, Xiaowei; Ai, Jing; Zhai, Yun; Liang, Zhongjie; Wang, Ying; Chen, Yi; Li, Chunpu; Zhao, Fei; Jiang, Hualiang; Geng, Meiyu; Luo, Cheng; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6804 - 6820