1-苄基-4-羟基-5-氮杂吲哚合成路线 （共 5 条）
反应条件
tributyl-amine in diphenylether; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran T=195°C; 1 h;
参考文献
BIOVITRUM AB
Patent: WO2004/828 A1, 2003 ;
WO 2004/000828 A1
反应条件
sodium azide 1.) 0 deg C, 1,5 h, 2.) 195 to 200 deg C,;
参考文献
Mahadevan,Indumathy; Rasmussen, Malcolm
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 359 - 367
参考文献
Journal of Heterocyclic Chemistry, , vol. 29, # 2 p. 359 - 367
反应条件
1: 79 percent / Na, liquid ammonia 2: 78 percent / phosphorus oxychloride / 5 h / 180 °C View Scheme
参考文献
Mahadevan,Indumathy; Rasmussen, Malcolm
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 359 - 367
反应条件
1: 79 percent / Na, liquid ammonia 2: 78 percent / phosphorus oxychloride / 5 h / 180 °C 3: 96 percent / H2 / 10percent Pd/C / ethanol View Scheme
参考文献
Mahadevan,Indumathy; Rasmussen, Malcolm
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 359 - 367
