2-氨基-4,5-二甲氧基苯腈合成路线 （共 16 条）
反应条件
lithium; phenyllithium in tetrahydrofuran; diethyl ether; water; benzene
参考文献
N.V. Koninklijke Pharmaceutische Fabrieken v/h Brocades-Stheeman en Pharmacia
Patent: US3980650 A1, 1976 ;
反应条件
1: phenylsulfonyl chloride 2: 69 percent / AcOH / acetonitrile / 0.17 h / 160 °C / microwave irradiation View Scheme
参考文献
Yoon, David S.; Han, Ying; Stark, Todd M.; Haber, James C.; Gregg, Brian T.; Stankovich, Sara B.
Organic Letters, 2004 , vol. 6, # 25 p. 4775 - 4778
反应条件
1: 94 percent / CaCO3 / H2O; CH2Cl2 / 1) 0-5 deg C, 1 h; 2) 20 deg C, 20 h;
2: 90 percent / ethyl acetate / 20 h / 0 °C
View Scheme
参考文献
Honkanen; Pippuri; Kairisalo; et al.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 4 p. 797 - 798
反应条件
1: POCl3 / CHCl3
2: 48 percent / ZnCl2 / N,N-dimethyl-acetamide / 2 h / Heating
View Scheme
参考文献
Campbell, Simon F.; Hardstone, J. David; Palmer, Michael, J.
Tetrahedron Letters, 1984 , vol. 25, # 42 p. 4813 - 4816
反应条件
1: in diethyl ether
T=20°C;
2: With hydrogenchloride; water in diethyl ether
参考文献
Kobayashi, Kazuhiro; Okamura, Yuta; Konishi, Hisatoshi
Synthesis, 2009 , # 9 art. no. F24508SS, p. 1494 - 1498
反应条件
hydrogenchloride; sodium hydroxide; stannous chloride; sodium nitrite in water
参考文献
Morton-Norwich Products, Inc.
Patent: US4001269 A1, 1977 ;
