5-氨基-1-叔丁基-1H-吡咯-3-甲腈合成路线 （共 9 条）
反应条件
potassium hydroxide in methanol T=20 - 30°C; 12 h; Industry scale; Product distribution / selectivity;
参考文献
WO2012/78802 A1, ;
Page/Page column 35 ;
反应条件
1: With acetic acid in ethanol 0.75 h; Heating / reflux; 2: With potassium hydroxide in ethanol 0.75 h; Heating / reflux;
参考文献
WO2008/67121 A2, ;
Page/Page column 70; 71 ;
反应条件
1: acetic acid / toluene; tert-butyl alcohol / 4 h / -10 - 82 °C / Industry scale 2: potassium hydroxide / methanol / 12 h / 20 - 30 °C / Industry scale View Scheme
反应条件
1: toluene-4-sulfonic acid / toluene / 95 °C 2: AlCl3, aluminium chloride / anhydrous xylene / 8 h / Reflux View Scheme
参考文献
Allegretti, Marcello; Anacardio, Roberto; Cesta, M. Candida; Curti, Roberto; Mantovanini, Marco; Nano, Giuseppe; Topai, Alessandra; Zampella, Giuseppe
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 209 - 213
反应条件
toluene-4-sulfonic acid in toluene T=95°C;
参考文献
Allegretti, Marcello; Anacardio, Roberto; Cesta, M. Candida; Curti, Roberto; Mantovanini, Marco; Nano, Giuseppe; Topai, Alessandra; Zampella, Giuseppe
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 209 - 213
反应条件
1: toluene-4-sulfonic acid / toluene / 95 °C 2: AlCl3, aluminium chloride / anhydrous xylene / 8 h / Reflux 3: hydrogenchloride / 70 °C View Scheme
参考文献
Allegretti, Marcello; Anacardio, Roberto; Cesta, M. Candida; Curti, Roberto; Mantovanini, Marco; Nano, Giuseppe; Topai, Alessandra; Zampella, Giuseppe
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 209 - 213
反应条件
acetic acid 1 h; RefluxInert atmosphere; regioselective reaction;
参考文献
Groth, Ulrich; Iaroshenko, Viktor O.; Wang, Yan; Wesch, Thomas
Synlett, 2009 , # 3 p. 456 - 460
反应条件
1: in propan-1-ol
T=20°C;
2: With hydrogenchloride in propan-1-ol; water
T=4 - 100°C; 20 h;
参考文献
PHARMACIA ITALIA S.p.A.
Patent: WO2005/63747 A1, 2005 ;
Location in patent: Page/Page column 40 ;
WO 2005/063747 A1
反应条件
1: With hydrogenchloride in ethanol
2 h; Heating / reflux;
2: With sodium hydroxide in water
参考文献
LEXICON PHARMACEUTICALS, INC.
Patent: WO2008/67121 A2, 2008 ;
Location in patent: Page/Page column 70; 71 ;
