4-甲酰基-2-甲氧基-3-硝基乙酸苯酯合成路线 （共 18 条）
反应条件
nitric acid Nitration;
参考文献
Magnus; Westlund
Tetrahedron Letters, 2000 , vol. 41, # 49 p. 9369 - 9372
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate
参考文献
Pfizer Inc.
Patent: US4287341 A1, 1981 ;
反应条件
1: With sodium acetate; sodium hydroxide in water T=20°C; 3 h; 2: With nitric acid in water T=-5°C; 3 h; regioselective reaction;
参考文献
Wada, Yasufumi; Harayama, Yu; Kamimura, Daigo; Yoshida, Masako; Shibata, Tomoyuki; Fujiwara, Kousaku; Morimoto, Koji; Fujioka, Hiromichi; Kita, Yasuyuki
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4959 - 4976
参考文献
Magnus, Philip; Gazzard, Lewis; Hobson, Lindsay; Payne, Andrew H.; Rainey, Trevor J.; Westlund, Neil; Lynch, Vince
Tetrahedron, 2002 , vol. 58, # 17 p. 3423 - 3444
反应条件
nitric acid Title compound not separated from byproducts;
参考文献
Williams, Robert M.; Cao, Jianhua; Tsujishima, Hidekazu; Cox, Rhona J.
Journal of the American Chemical Society, 2003 , vol. 125, # 40 p. 12172 - 12178
反应条件
nitric acid T=2 - 6°C; 0.25 h;
参考文献
Dharmasens, Priyanthi; Oliveira-Campos, Ana-M. R.; Queiroz, Maria-Joao R. P.; Shannon, Patric V. R.
Journal of Chemical Research, Miniprint, 1996 , # 1 p. 316 - 363
反应条件
2: 27 percent / conc. HNO3 / 0.75 h View Scheme
参考文献
Magnus; Westlund
Tetrahedron Letters, 2000 , vol. 41, # 49 p. 9369 - 9372
反应条件
hydrogenchloride; nitric acid 1.) 2 deg C - 6 deg C, 15 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Dharmasens, Priyanthi; Oliveira-Campos, Ana-M. R.; Queiroz, Maria-Joao R. P.; Shannon, Patric V. R.
Journal of Chemical Research, Miniprint, 1996 , # 1 p. 316 - 363
反应条件
1: potassium carbonate / methanol / 16 h / 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 16 h View Scheme
参考文献
Bayer Pharma Aktiengesellschaft; SCOTT, William Johnston; PETROV, Orlin
Patent: WO2012/62743 A1, 2012 ;
WO 2012/062743 A1
反应条件
methanol; sodium hydrogencarbonate
参考文献
MacDonald
Journal of the Chemical Society, 1948 , p. 376
