D-苏式-鞘胺醇-1-磷酸合成路线 （共 15 条）
反应条件
trimethylsilyl bromide in dichloromethane T=0°C; 2 h;
参考文献
Lim, Hyun Suk; Oh, Yong Seok; Suh, Pann Ghill; Chung, Sung Kee
Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 237 - 240
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=45°C; 2 h;
参考文献
BIOLAB LTD.
Patent: WO2005/68480 A1, 2005 ;
Location in patent: Page/Page column 21-22 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=45°C; 72 h;
参考文献
Kratzer, Bernd; Schmidt, Richard R.
Liebigs Annalen, 1995 , # 6 p. 957 - 964
反应条件
trimethylsilyl bromide in dichloromethane T=20°C; 3 h;
参考文献
Murakami, Teiichi; Furusawa, Kiyotaka; Tamai, Tadakazu; Yoshikai, Kazuyoshi; Nishikawa, Masazumi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1115 - 1119
反应条件
1.1: 72 percent / CBr4; pyridine / 2 h / 4 - 20 °C 2.1: 85 percent / (CH3)3SiCl / methanol / 24 h / 0 - 20 °C 3.1: (CH3)3SiBr / CH2Cl2 / 1 h / 0 - 20 °C 3.2: 73 percent / H2O View Scheme
参考文献
Qiao, Lixin; Kozikowski, Alan P.; Olivera, Ana; Spiegel, Sarah
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 711 - 714
反应条件
1: tetrazole / acetonitrile 2: I2, pyridine, water / CH2Cl2 3: 56 percent / TFA / CH2Cl2 4: CDCl3 / 48 h / Irradiation View Scheme
参考文献
Qiao, Lixin; Kozikowski, Alan P.; Olivera, Ana; Spiegel, Sarah
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 711 - 714
反应条件
1: p-TsOH / benzene / Heating 2: NaOMe, MeOH 3: tetrazole / acetonitrile 4: I2, pyridine, water / CH2Cl2 5: 56 percent / TFA / CH2Cl2 6: CDCl3 / 48 h / Irradiation View Scheme
参考文献
Qiao, Lixin; Kozikowski, Alan P.; Olivera, Ana; Spiegel, Sarah
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 711 - 714
反应条件
1: 56 percent / TFA / CH2Cl2 2: CDCl3 / 48 h / Irradiation View Scheme
参考文献
Qiao, Lixin; Kozikowski, Alan P.; Olivera, Ana; Spiegel, Sarah
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 711 - 714
反应条件
1: 91 percent / Ph3P, H2O, pyridine 2: 92 percent / NaHCO3 / dioxane; H2O 3: tetrazole / CH2Cl2; acetonitrile / 0.5 h 4: iodine, pyridine, water / CH2Cl2 5: 95 percent / 33percent HNMe2 / ethanol / 72 h / 45 °C 6: 75 percent / tetrabutylammonium fluoride / tetrahydrofuran / 72 h / 45 °C View Scheme
参考文献
Kratzer, Bernd; Schmidt, Richard R.
Tetrahedron Letters, 1993 , vol. 34, # 11 p. 1761 - 1764
反应条件
1: 92 percent / NaHCO3 / dioxane; H2O 2: tetrazole / CH2Cl2; acetonitrile / 0.5 h 3: iodine, pyridine, water / CH2Cl2 4: 95 percent / 33percent HNMe2 / ethanol / 72 h / 45 °C 5: 75 percent / tetrabutylammonium fluoride / tetrahydrofuran / 72 h / 45 °C View Scheme
参考文献
Kratzer, Bernd; Schmidt, Richard R.
Tetrahedron Letters, 1993 , vol. 34, # 11 p. 1761 - 1764
