D-苏式-鞘胺醇-1-磷酸合成路线 （共 15 条）
反应条件
1: tetrazole / CH2Cl2; acetonitrile / 0.5 h 2: iodine, pyridine, water / CH2Cl2 3: 95 percent / 33percent HNMe2 / ethanol / 72 h / 45 °C 4: 75 percent / tetrabutylammonium fluoride / tetrahydrofuran / 72 h / 45 °C View Scheme
参考文献
Kratzer, Bernd; Schmidt, Richard R.
Tetrahedron Letters, 1993 , vol. 34, # 11 p. 1761 - 1764
反应条件
1: 95 percent / 33percent HNMe2 / ethanol / 72 h / 45 °C 2: 75 percent / tetrabutylammonium fluoride / tetrahydrofuran / 72 h / 45 °C View Scheme
参考文献
Kratzer, Bernd; Schmidt, Richard R.
Tetrahedron Letters, 1993 , vol. 34, # 11 p. 1761 - 1764
反应条件
1: 25 percent / acetate buffer, CaCl2, phospholipase D, butylatede hydroxytoluene / diethyl ether / 4 h / 30 °C 2: 30 percent / phosphate buffer, phospholipase C, butylated hydroxytoluene / diethyl ether / 4 h / 30 °C View Scheme
参考文献
Morigaki, Eiji; Miura, Yoshie; Takahata, Kyoya; Tada, Mikiro; Nakajima, Shuhei; Baba, Naomichi
Journal of Chemical Research - Part S, 1998 , # 12 p. 774 - 775
反应条件
in chloroform-d1 48 h; Irradiation;
参考文献
Qiao, Lixin; Kozikowski, Alan P.; Olivera, Ana; Spiegel, Sarah
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 711 - 714
反应条件
1: [33P]-Sphingosine-1-phosphate With N,O-bis-(trimethylsilyl)-acetamide T=20°C; 2: biotin acid chloride With N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C; Further stages.;
参考文献
Nussbaumer, Peter; Hornillos, Valentin; Ghobrial, Michael; Ullrich, Thomas
Chemistry and Physics of Lipids, 2008 , vol. 151, # 2 p. 125 - 128
