2-溴-5-氯苯甲酸甲酯合成路线

参考文献

Merck and Co., Inc.
Patent: US6528503 B2, 2003 ;

参考文献

ROTTAPHARM SPA; STASI, Luigi Piero; ROVATI, Lucio Claudio; ARTUSI, Roberto; COLACE, Fabrizio; MANDELLI, Stefano; PERUGINI, Lorenzo
Patent: WO2013/92893 A1, 2013 ;
Location in patent: Page/Page column 34; 35 ;

79-37-8草酰氯+

21739-93-52-溴-5-氯苯甲酸

27007-53-02-溴-5-氯苯甲酸甲酯

参考文献

Cell Therapeutics, Inc.
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21739-93-52-溴-5-氯苯甲酸+

18107-18-1三甲基硅烷化重氮甲烷

27007-53-02-溴-5-氯苯甲酸甲酯

参考文献

Dydio, Pawel; Reek, Joost N. H.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 14 p. 3878 - 3882
Angew. Chem., 2013 , vol. 125, # 14 p. 4132

21739-93-52-溴-5-氯苯甲酸+

77-78-1硫酸二甲酯

27007-53-02-溴-5-氯苯甲酸甲酯

参考文献

Biswas, Kaustav; Peterkin, Tanya A. N.; Bryan, Marian C.; Arik, Leyla; Lehto, Sonya G.; Sun, Hong; Hsieh, Feng-Yin; Xu, Cen; Fremeau, Robert T.; Allen, Jennifer R.
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14221-01-3四三苯基膦钯+

27007-53-02-溴-5-氯苯甲酸甲酯

439117-38-15-氯-2-氰基苯甲酸甲酯

参考文献

Merck and Co., Inc.
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557-21-1氰化锌+

27007-53-02-溴-5-氯苯甲酸甲酯

439117-38-15-氯-2-氰基苯甲酸甲酯

参考文献

MERCK SHARP and DOHME CORP.; XU, Libo; CHOBANIAN, Harry; CAMPBELL, Brian, T.; GUO, Yan; PIO, Barbara; ZHANG, Rui
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Location in patent: Page/Page column 25 ;

27007-53-02-溴-5-氯苯甲酸甲酯+

544-92-3氰化亚铜

27007-54-1+

439117-38-15-氯-2-氰基苯甲酸甲酯

参考文献

Nelson, Todd D.; LeBlond, Carl R.; Frantz, Doug E.; Matty, Louis; Mitten, Jeffrey V.; Weaver, Damian G.; Moore, Jeffrey C.; Kim, Jaehon M.; Boyd, Russell; Kim, Pei-Yi; Gbewonyo, Kodzo; Brower, Mark; Sturr, Michael; McLaughlin, Kathleen; McMasters, Daniel R.; Kress, Michael H.; McNamara, James M.; Dolling, Ulf H.
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3620 - 3627

27007-53-02-溴-5-氯苯甲酸甲酯+

557-21-1氰化锌

439117-38-15-氯-2-氰基苯甲酸甲酯

参考文献

Morrissette, Matthew M.; Stauffer, Kenneth J.; Williams, Peter D.; Lyle, Terry A.; Vacca, Joseph P.; Krueger, Julie A.; Lewis, S. Dale; Lucas, Bobby J.; Wong, Bradley K.; White, Rebecca B.; Miller-Stein, Cynthia; Lyle, Elizabeth A.; Wallace, Audrey A.; Leonard, Yvonne M.; Welsh, Denise C.; Lynch, Joseph J.; McMasters, Daniel R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 16 p. 4161 - 4164

27007-53-02-溴-5-氯苯甲酸甲酯+

544-92-3氰化亚铜

27007-54-1+

439117-38-15-氯-2-氰基苯甲酸甲酯

参考文献

Nelson, Todd D.; LeBlond, Carl R.; Frantz, Doug E.; Matty, Louis; Mitten, Jeffrey V.; Weaver, Damian G.; Moore, Jeffrey C.; Kim, Jaehon M.; Boyd, Russell; Kim, Pei-Yi; Gbewonyo, Kodzo; Brower, Mark; Sturr, Michael; McLaughlin, Kathleen; McMasters, Daniel R.; Kress, Michael H.; McNamara, James M.; Dolling, Ulf H.
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3620 - 3627