6-氯吲哚-2-甲酸乙酯合成路线 （共 16 条）
反应条件
dirhodium tetraacetate in toluene Inert atmosphereReflux;
参考文献
Wang, Rui; Shi, Hong-Fan; Zhao, Jing-Feng; He, Yan-Ping; Zhang, Hong-Bin; Liu, Jian-Ping
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1760 - 1762
反应条件
iron; acetic acid in ethanol 4 h; Reflux;
参考文献
Gore, Vivek; Patel, Pranav; Chang, Chih-Tsung; Sivendran, Sashikala; Kang, Namin; Ouedraogo, Yannick P.; Gravel, Sylvie; Powell, William S.; Rokach, Joshua
Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3725 - 3732
反应条件
1: in toluene T=20°C; Wittig reaction; 2: With triphenylphosphine; [MoO2Cl2(dmf)2] in toluene 24 h; Heating; Further stages.;
参考文献
Sanz, Roberto; Escribano, Jaime; Pedrosa, Maria R.; Aguado, Rafael; Arnaiz, Francisco J.
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 713 - 718
反应条件
hydrogenchloride in glacial HOAc; ethanol; dichloromethane
参考文献
Wyeth
Patent: US2003/144282 A1, 2003 ;
反应条件
1: potassium ethoxide / ethanol; diethyl ether / 22 h / sonication 2: 16.8 g / AcOH; Fe / ethanol / 4 h / Heating View Scheme
参考文献
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; DOEMLING, Alexander; HOLAK, Tad
Patent: WO2011/106650 A2, 2011 ;
WO 2011/106650 A2
反应条件
tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate in acetonitrile T=80°C; Heck-Jeffery amination; 96 h; Inert atmosphere;
参考文献
McNulty, James; Keskar, Kunal
European Journal of Organic Chemistry, 2011 , # 34 p. 6902 - 6908
参考文献
Bornhop, Darryl J.; Manning, H. Charles; Bai, Mingfeng; Wyatt, Shelby K.
Patent: US2006/147379 A1, 2006 ;
Location in patent: Page/Page column 16-17 ;
反应条件
Bi(NO3)3; PPA in methanol 2 h; Reflux;
参考文献
Sudhakara; Jayadevappa; Mahadevan; Hulikal, Vijaykumar
Synthetic Communications, 2009 , vol. 39, # 14 p. 2506 - 2515
反应条件
1: NaOEt / ethanol / 2 h / -10 °C 2: toluene / 3 h / Heating View Scheme
参考文献
Wang, Rui; Shi, Hong-Fan; Zhao, Jing-Feng; He, Yan-Ping; Zhang, Hong-Bin; Liu, Jian-Ping
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1760 - 1762
反应条件
1.1: 66 percent / MnO2 2.1: toluene / 20 °C 2.2: 50 percent / PPh3 / MoO2Cl2(dmf)2 / toluene / 24 h / Heating View Scheme
参考文献
Sanz, Roberto; Escribano, Jaime; Pedrosa, Maria R.; Aguado, Rafael; Arnaiz, Francisco J.
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 713 - 718
