4-羟基-7-甲氧基喹啉-2-酮合成路线 （共 9 条）
反应条件
trichlorophosphate T=95°C;
参考文献
Faber; Steininger; Kappe
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1081 - 1087
反应条件
PPA 6 h; 120-140 deg C;
参考文献
Shobana, N.; Yeshoda, P.; Shanmugam, P.
Tetrahedron, 1989 , vol. 45, # 3 p. 757 - 762
反应条件
in toluene 2 h; Heating;
参考文献
Knierzinger; Wolfbeis
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 2 p. 225 - 229
反应条件
trichlorophosphate T=100°C;
参考文献
Audisio, Davide; Messaoudi, Samir; Cegielkowski, Lukasz; Peyrat, Jean-Francois; Brion, Jean-Daniel; Methy-Gonnot, Delphine; Radanyi, Christine; Renoir, Jack-Michel; Alami, Mouad
ChemMedChem, 2011 , vol. 6, # 5 p. 804 - 815
反应条件
1: 90 percent 2: 75 percent / polyphosphoric acid / 6 h / 120-140 deg C View Scheme
参考文献
Shobana, N.; Yeshoda, P.; Shanmugam, P.
Tetrahedron, 1989 , vol. 45, # 3 p. 757 - 762
反应条件
1: With trichlorophosphate T=115°C; 3 h; 2: With sodium hydroxide in water T=0°C; pH=10;
参考文献
VIROBAY, INC.
Patent: WO2007/5838 A2, 2007 ;
Location in patent: Page/Page column 71-72 ;
反应条件
in ethyl acetate; trichlorophosphate
参考文献
Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P. V. K. Suresh; Scola, Paul Michael
Patent: US2013/115190 A1, 2013 ;
Location in patent: Page/Page column ;
反应条件
sulfuryl dichloride in 1,4-dioxane
参考文献
Faber; Steininger; Kappe
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1081 - 1087
反应条件
hydrazine hydrate
0.05 h; microwave irradiation;
参考文献
Dandia, Anshu; Arya, Kapil; Dhaka, Nidhi
Journal of Chemical Research, 2006 , # 3 p. 192 - 198
