1.1: 91 percent / benzene; methanol / 0 °C 2.1: 91 percent / HCl / ethyl acetate / 0.5 h / 25 °C 3.1: HOAt; EDCI / CH2Cl2 / 0.25 h / 0 °C 3.2: 78 percent / CH2Cl2 / 12 h 4.1: 100 percent / HCl / ethyl acetate / 0.5 h / 25 °C 5.1: 68 percent / HOAt; EDCI; NaHCO3 / CH2Cl2 / 12 h / 0 °C 6.1: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 1.5 h / 25 °C 7.1: HOAt; EDCI / CH2Cl2 / 15 h / -20 °C 7.2: 49 percent / CH2Cl2 / 4 h 8.1: 100 percent / Zn; 90percent aq. AcOH / 2 h / 0 °C 9.1: 83 percent / HOAt; EDCI / CH2Cl2 / 6 h / 0 °C 10.1: Zn; 90percent aq. AcOH / 2 h / 0 °C 11.1: I2 / CH2Cl2; methanol / 2 h / 25 °C 12.1: 3 M HCl / dioxane / 0.5 h / 25 °C 13.1: HOAt; EDCI / CH2Cl2 / 6 h / 0 °C 14.1: TFA; anisole / 6 h / 25 °C 15.1: DMAP; EDCI / CH2Cl2 / 0.5 h / 25 °C 15.2: CH2Cl2 / 72 h / 25 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=25&deg;C;&nbsp;Acylation;&nbsp;pH=8;&nbsp;12&nbsp;h;&nbsp;<br /> &nbsp;