1: in tetrahydrofuran T=25°C; 2: With acetic anhydride T=120°C; 0.0666667 h; microwave irradiation; Further stages.;

ammonia; cadmium calcium phosphate T=350 - 400°C; flow-type reactor;

1.1: tetrahydrofuran; diethyl ether / 0.17 h / 0 °C / Inert atmosphere 2.1: titanium(IV) isopropylate; cyclopentyl-magnesium chloride / tetrahydrofuran; diethyl ether / 1.5 h / -78 - -30 °C / Inert atmosphere 2.2: 0.17 h / -78 - 0 °C / Inert atmosphere 2.3: 0 - 20 °C / Inert atmosphere 3.1: hydrogenchloride; boron trifluoride diethyl etherate; mercury(II) oxide / tetrahydrofuran; water / 100 °C / Inert atmosphere View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -20 °C / Inert atmosphere 1.2: 0.5 h / -78 °C / Inert atmosphere 2.1: titanium(IV) isopropylate; cyclopentyl-magnesium chloride / tetrahydrofuran; diethyl ether / 1.5 h / -78 - -30 °C / Inert atmosphere 2.2: 0.17 h / -78 - 0 °C / Inert atmosphere 2.3: 0 - 20 °C / Inert atmosphere 3.1: hydrogenchloride; boron trifluoride diethyl etherate; mercury(II) oxide / tetrahydrofuran; water / 100 °C / Inert atmosphere View Scheme

1.1: titanium(IV) isopropylate; cyclopentyl-magnesium chloride / tetrahydrofuran; diethyl ether / 1.5 h / -78 - -30 °C / Inert atmosphere 1.2: 0.17 h / -78 - 0 °C / Inert atmosphere 1.3: 0 - 20 °C / Inert atmosphere 2.1: hydrogenchloride; boron trifluoride diethyl etherate; mercury(II) oxide / tetrahydrofuran; water / 100 °C / Inert atmosphere View Scheme

1: in diethyl ether Arylation; Heating; 2: in toluene Arylation; 8 h; Heating;