2,4-二甲基-5-溴吡啶合成路线 （共 7 条）
反应条件
sulfuric acid; bromine T=155 - 175°C; 24 h;
参考文献
Dunn, Allan D.; Guillermic, Sandrine
Zeitschrift fuer Chemie (Stuttgart, Germany), 1988 , vol. 28, # 2 p. 59 - 60
参考文献
Hoechst Aktiengesellschaft
Patent: US5004748 A1, 1991 ;
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite in water 1.) 10 deg C, 2.) room temp., 30 min, 3.) 80 deg C, 20 min;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 626 - 633
参考文献
Smith Kline and French Laboratories Limited
Patent: US4154834 A1, 1979 ;
US 4154834 A
反应条件
1: With isopropylmagnesium chloride in tetrahydrofuran T=20°C; 2: With methanol regioselective reaction;
参考文献
Thalhammer, Armin; Mecinovic, Jasmin; Loenarz, Christoph; Tumber, Anthony; Rose, Nathan R.; Heightman, Tom D.; Schofield, Christopher J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 1 p. 127 - 135
参考文献
Hoechst Aktiengesellschaft
Patent: US5004748 A1, 1991 ;
反应条件
1: 59 percent / 35percent H2O2 / acetic acid / 20 h / 110 °C
2: 64 percent / Et3N / acetonitrile / 20 h / Heating
View Scheme
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 626 - 633
