1-(4-氟苯基甲基)哌嗪合成路线 （共 4 条）
反应条件
potassium carbonate; potassium iodide in acetonitrile Reflux;
参考文献
ASKA Pharmaceutical Co., Ltd; Okada, Makoto; Hasumi, Koichi; Nishimoto, Takahiro; Yoshida, Miwa; Ishitani, Kouki; Aotsuka, Tomoji; Kanazawa, Hashime
Patent: US2013/85127 A1, 2013 ;
Location in patent: Paragraph 0299; 0300; 0301 ;
反应条件
1: tetrahydrofuran / 0 - 20 °C 2: thionyl chloride / dichloromethane / 20 °C / |Reflux 3: potassium iodide; potassium carbonate / acetonitrile / |Reflux View Scheme
参考文献
ASKA Pharmaceutical Co., Ltd; Okada, Makoto; Hasumi, Koichi; Nishimoto, Takahiro; Yoshida, Miwa; Ishitani, Kouki; Aotsuka, Tomoji; Kanazawa, Hashime
Patent: US2013/85127 A1, 2013 ;
反应条件
1: thionyl chloride / dichloromethane / 20 °C / |Reflux 2: potassium iodide; potassium carbonate / acetonitrile / |Reflux View Scheme
参考文献
ASKA Pharmaceutical Co., Ltd; Okada, Makoto; Hasumi, Koichi; Nishimoto, Takahiro; Yoshida, Miwa; Ishitani, Kouki; Aotsuka, Tomoji; Kanazawa, Hashime
Patent: US2013/85127 A1, 2013 ;
反应条件
1: tetrahydrofuran / 0 - 20 °C 2: thionyl chloride / dichloromethane / 20 °C / |Reflux 3: potassium iodide; potassium carbonate / acetonitrile / |Reflux View Scheme
参考文献
ASKA Pharmaceutical Co., Ltd; Okada, Makoto; Hasumi, Koichi; Nishimoto, Takahiro; Yoshida, Miwa; Ishitani, Kouki; Aotsuka, Tomoji; Kanazawa, Hashime
Patent: US2013/85127 A1, 2013 ;
