氯代双(4-氟苯基甲烷)合成路线 （共 13 条）
反应条件
1: acetonitrile / 1.5 h / 80 °C
2: H2, NH3, Raney nickel / ethanol / 5 h / 60 °C / 45600 Torr
View Scheme
参考文献
Dhainaut, Alain; Regnier, Gilbert; Atassi, Ghanem; Pierre, Alain; Leonce, Stephane; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2481 - 2496
反应条件
in ethanol
24 h; Heating;
参考文献
Gubert; Braso; Sacristan; Ortiz
Arzneimittel-Forschung/Drug Research, 1987 , vol. 37, # 10 p. 1103 - 1107
反应条件
trifluorormethanesulfonic acid
T=130°C; 2 h;
参考文献
Rigo, Benoit; Gautret, Philippe; Legrand, Anne; Henichart, Jean-Pierre; Couturier, Daniel
Synlett, 1997 , vol. 1997, # 8 p. 998 - 1000
