(3-甲酰基-1H-吲哚-1-基)乙酸乙酯合成路线 （共 6 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=15 - 20°C; 16.5 h;
参考文献
NOVO NORDISK A/S
Patent: WO2004/80480 A1, 2004 ;
Location in patent: Page/Page column 225-226 ;
反应条件
sodium hydroxide 0.5 h; Ambient temperature;
参考文献
Moriya, Tamon; Hagio, Katsuaki; Yoneda, Naoto
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 6 p. 1711 - 1721
反应条件
1: POCl3 / 1 h / 35 °C 2: 50percent NaH / dimethylformamide; benzene / 4 h / Ambient temperature View Scheme
参考文献
Courant, Jacqueline; Leblois, Danielle; Tandon, Manju; Robert-Piessard, Sylvie; le Baut, Guillaume; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 145 - 154
反应条件
1: 96 percent / benzene / 2 h / Heating; removing the liberated water 2: 80 percent / ethanol / Ambient temperature; overnight; var.: solvent, time 3: 76 percent / 1percent aq. NaOH / 0.5 h / Ambient temperature View Scheme
参考文献
Moriya, Tamon; Hagio, Katsuaki; Yoneda, Naoto
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 6 p. 1711 - 1721
反应条件
1: 80 percent / ethanol / Ambient temperature; overnight; var.: solvent, time 2: 76 percent / 1percent aq. NaOH / 0.5 h / Ambient temperature View Scheme
参考文献
Moriya, Tamon; Hagio, Katsuaki; Yoneda, Naoto
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 6 p. 1711 - 1721
反应条件
1: With sodium hydroxide; water in 1,4-dioxane T=20°C; 96 h; 2: With hydrogenchloride in 1,4-dioxane; water
参考文献
NOVO NORDISK A/S
Patent: WO2004/80480 A1, 2004 ;
Location in patent: Page/Page column 226 ;
