(2S,3S)-3-羟基-2-(4-甲氧基苯基)-2,3-二氢-1,5-苯并硫氮杂卓-4(5H)-酮合成路线 （共 5 条）
反应条件
(i) NaH, DMSO, (ii) /BRN= 5388283/, (iii) aq. HBr, AcOH; Multistep reaction;
参考文献
Miyazaki; Iwakuma; Tanaka
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 9 p. 2889 - 2893
反应条件
1: 93.9 percent / aq. K2CO3 / ethyl acetate / 8 h / Heating View Scheme
参考文献
Yamada, Shin-Ichi; Yoshioka, Ryuzo; Shibatani, Takeji
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 12 p. 1922 - 1927
反应条件
acetic anhydride; pyridine in water; dimethyl sulfoxide
参考文献
Zamon Group S.p.A.
Patent: US6114523 A1, 2000 ;
反应条件
pyridine; dimethyl sulfoxide
24 h; Ambient temperature;
参考文献
Yamada, Shin-Ichi; Mori, Yoshikazu; Morimatsu, Katsuji; Ishizu, Yoshinori; Ozaki, Yasuhiko; Yoshioka, Ryuzo; Nakatani, Tadashi; Seko, Hiroyasu
Journal of Organic Chemistry, 1996 , vol. 61, # 24 p. 8586 - 8590
反应条件
1: 84.1 percent / DMSO, Py / 24 h / Ambient temperature
2: 86.7 percent / NaOH, H2O / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Yamada, Shin-Ichi; Mori, Yoshikazu; Morimatsu, Katsuji; Ishizu, Yoshinori; Ozaki, Yasuhiko; Yoshioka, Ryuzo; Nakatani, Tadashi; Seko, Hiroyasu
Journal of Organic Chemistry, 1996 , vol. 61, # 24 p. 8586 - 8590
