7H-吡咯并[2,3-D]嘧啶合成路线 （共 11 条）
反应条件
1: N-iodo-succinimide / acetonitrile / 3 h
2: triethylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 3 h
3: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h
View Scheme
参考文献
Billedeau, Roland Joseph; Kondru, Rama K.; Lopez-Tapia, Francisco Javier; Lou, Yan; Owens, Timothy D.; Qian, Yimin; So, Sung-Sau; Thakkar, Kshitij C.; Wanner, Jutta
Patent: US2012/295885 A1, 2012 ;
