乙基(2E)-[(4-溴苯基)亚肼基](氯)乙酸酯合成路线 （共 5 条）
反应条件
1: 4-bromo-aniline With hydrogenchloride in water 2: With sodium nitrite in water T=15°C; 3: chloroacetic acid ethyl ester With sodium acetate in ethanol; water T=20°C;
参考文献
Donohue, Sean R.; Dannals, Robert F.; Halldin, Christer; Pike, Victor W.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2961 - 2970
反应条件
1: 4-bromo-aniline With hydrogenchloride; sodium nitrite in water T=0°C; 2: ethyl 2-chloro-3-oxobutanoate With sodium acetate in ethanol; water T=0°C; 4 h;
参考文献
Matiychuk, Vasyl S.; Potopnyk, Mykhaylo A.; Luboradzki, Roman; Obushak, Mykola D.
Synthesis, 2011 , # 11 p. 1799 - 1803
反应条件
ethanol; sodium acetate
参考文献
Bowack; Lapworth
Journal of the Chemical Society, 1905 , vol. 87, p. 1859
参考文献
Huisgen; Koch
Justus Liebigs Annalen der Chemie, 1955 , vol. 591, p. 200,221
反应条件
sodium ethanolate in diethyl ether; ethanol 12 h; Ambient temperature;
参考文献
Bernard; Cocco; Maccioni; Plumitallo
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 4 p. 259 - 271
