4-乙烯基-苯甲酸乙基酯合成路线 （共 24 条）
反应条件
1: 4-iodobenzoic acid ethyl ester With pentane-1,5-diylbis(magnesium bromide) in tetrahydrofuran T=-78 - 20°C; 2: allyl bromide in tetrahydrofuran T=20°C;
参考文献
Yang, Xiaoyin; Knochel, Paul
Synlett, 2004 , # 1 p. 81 - 84
反应条件
2C8H8NO2(1-)*2Cl(1-)*2Pd(2+); tetrabutylammomium bromide; potassium carbonate in water T=120°C; Suzuki-Miyaura coupling; 8 h; Sealed vessel;
参考文献
Alacid, Emilio; Najera, Carmen
Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2321 - 2327
反应条件
1: vinyl-magnesium chloride With zinc dibromide in tetrahydrofuran; 1-methyl-pyrrolidin-2-one Inert atmosphere; 2: p-EtOC(O)C6H4Cl With bis(acetylacetonate)nickel(II); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=50°C; 12 h; Inert atmosphere;
参考文献
Yamamoto, Tetsuya; Yamakawa, Tetsu
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3603 - 3605
反应条件
tetrabutyl ammonium fluoride; palladium dichloride in tetrahydrofuran T=65°C; Hiyama coupling; 8 h;
参考文献
Chatterjee, Tanmay; Dey, Raju; Ranu, Brindaban C.
New Journal of Chemistry, 2011 , vol. 35, # 5 p. 1103 - 1110
反应条件
1: 4-iodobenzoic acid ethyl ester With isopropylmagnesium chloride in tetrahydrofuran; ethylene glycol dimethyl ether T=-20°C; 2: in tetrahydrofuran; ethylene glycol dimethyl ether 0.333333 h; 3: ethenyl nonaflate With iron (III) acetylacetonate in tetrahydrofuran; ethylene glycol dimethyl ether T=20°C; 0.5 h;
参考文献
Dunet, Guillaume; Knochel, Paul
Synlett, 2006 , # 3 p. 407 - 410
反应条件
tetrakis(triphenylphosphine) palladium(0) T=80°C; Stille cross-coupling; 5 h; Ionic liquid;
参考文献
Louaisil, Nicolas; Pham, Phuoc Dien; Boeda, Fabien; Faye, Djibril; Castanet, Anne-Sophie; Legoupy, Stephanie
European Journal of Organic Chemistry, 2011 , # 1 p. 143 - 149
反应条件
1: 1-bromo-4-ethenylbenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2.5 h; 2: chloroformic acid ethyl ester in tetrahydrofuran; hexane T=-78°C; 0.5 h;
参考文献
Martin, Sara E. S.; Watson, Donald A.
Journal of the American Chemical Society, 2013 , vol. 135, # 36 p. 13330 - 13333
反应条件
1: vinyl-magnesium chloride With zinc dibromide in tetrahydrofuran; 1-methyl-pyrrolidin-2-one Inert atmosphere; 2: 4-bromo-benzoic acid ethyl ester With bis(acetylacetonate)nickel(II); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=50°C; 6 h; Inert atmosphere;
参考文献
Yamamoto, Tetsuya; Yamakawa, Tetsu
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3603 - 3605
反应条件
1: ethyl 4-hydroxybenzoate O-trifalte With 1,1'-bis-(diphenylphosphino)ferrocene; bis(1,5-cyclooctadiene)nickel (0); N,N-dicyclohexylmethylamine Heck Reaction; Inert atmosphereGloveboxSealed tube; 2: 4-methoxy-1-vinyl-benzene With (SPY-5-31)-dichloro-(κ2(C,O)-(2-isopropyloxybenzylidene))(1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene)ruthenium T=100°C; 20 h; GloveboxInert atmosphereSealed tube;
参考文献
Min, Geanna K.; Bjerglund, Klaus; Kramer, Soren; Gogsig, Thomas M.; Lindhardt, Anders T.; Skrydstrup, Troels
Chemistry - A European Journal, 2013 , vol. 19, # 51 p. 17603 - 17607
反应条件
bis(dibenzylideneacetone)-palladium(0) in acetonitrile T=40°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Ikenaga, Kazutoshi; Kikukawa, Kiyoshi; Matsuda, Tsutomu
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1276 - 1280
