4,4’-二甲氧基-N-甲基二苯胺合成路线 （共 11 条）
反应条件
carbon dioxide; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; tris-(dibenzylideneacetone)dipalladium(0)
T=100°C; P=93086.6 Torr; 17 h;
参考文献
Smith, Catherine J.; Tsang, Melanie W.S.; Holmes, Andrew B.; Danheiser, Rick L.; Tester, Jefferson W.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 20 p. 3767 - 3781
反应条件
ammonium acetate; zinc in ethanol; ammonia
T=50°C; 4 h; Heating / reflux;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/121921 A2, 2007 ;
Location in patent: Page/Page column 47-48 ;
WO 2007/121921 A2
反应条件
carbon dioxide; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; tris-(dibenzylideneacetone)dipalladium(0)
T=100°C; P=93086.6 Torr; 48 h;
参考文献
Smith, Catherine J.; Tsang, Melanie W.S.; Holmes, Andrew B.; Danheiser, Rick L.; Tester, Jefferson W.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 20 p. 3767 - 3781
反应条件
PdCl(C6H4CH2CH2NH2)(P(C(CH3)3)2(C6H4C6H2(CH(CH3)2)3)); sodium t-butanolate in tetrahydrofuran; tert-butyl alcohol
T=20°C; 2 h;
参考文献
Fors, Brett P.; Watson, Donald A.; Biscoe, Mark R.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2008 , vol. 130, # 41 p. 13552 - 13554
反应条件
1: 73 percent / Et3N / CH2Cl2 / 17 h / 20 °C
2: 62 percent / Cs2CO3; 2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl; scCO2 / Pd2dba3 / 17 h / 100 °C / 93086.6 Torr
View Scheme
参考文献
Smith, Catherine J.; Tsang, Melanie W.S.; Holmes, Andrew B.; Danheiser, Rick L.; Tester, Jefferson W.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 20 p. 3767 - 3781
反应条件
potassium hydroxide; water; tetra-(n-butyl)ammonium iodide
1.) benzene, 88 deg C, 1 h, 2.) reflux, 5 h; Yield given. Multistep reaction;
参考文献
Dinnocenzo, J. P.; Banach, T. E.
Journal of the American Chemical Society, 1989 , vol. 111, # 23 p. 8646 - 8653
反应条件
n-Bu4N+*AsF6- in acetonitrile
T=15.1°C; 0.166667 h; ΔGet0, ΔH(excit.), ΔS(excit.), Ea, Ep; KineticsMechanismThermodynamic data;
参考文献
Dinnocenzo, J. P.; Banach, T. E.
Journal of the American Chemical Society, 1989 , vol. 111, # 23 p. 8646 - 8653
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
Ohta, Kiminori; Chiba, Yuki; Ogawa, Takumi; Endo, Yasuyuki
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5050 - 5053
参考文献
Imp.Chem.Ind.
Patent: US2184512 , 1936 ;
参考文献
Kainer; Hausser
Chemische Berichte, 1953 , vol. 86, p. 1563,1566
