potassium tert-butylate in diethyl ether T=0°C; 1 h;

trifluoromethylsulfonic anhydride; triethylamine in dichloromethane T=-70°C;

1: 74 percent / CH2Cl2 2: 55 percent / potassium tert-butoxide / diethyl ether / 1 h / 0 °C View Scheme

1: 99 percent / bromine / CCl4 / 8 h / Heating 2: 74 percent / CH2Cl2 3: 55 percent / potassium tert-butoxide / diethyl ether / 1 h / 0 °C View Scheme

in diethyl ether 3 h; Ambient temperatureother benzyl-Grignarad reagents, also 2-bromo-N-tert-butyl-2-phenylacetamide, var. time, solvents, and molar ratio substrate to reagent; Product distribution;