L-苯基丙氨酸盐酸盐(1:1)合成路线 （共 3 条）
反应条件
1: hydrogenchloride / water / 1 h / |Reflux 2: pyridine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 4 h / 20 °C 3: Rhizomucor miehei lipase / acetonitrile / 24 h / 30 °C / |Inert atmosphere; |Enzymatic reaction View Scheme
参考文献
Da Silva, Marcos Reinaldo; De Mattos, Marcos Carlos; De Oliveira, Maria Da Conceicao Ferreira; De Lemos, Telma Leda Gomes; Ricardo, Nagila Maria Pontes Silva; De Gonzalo, Gonzalo; Lavandera, Ivan; Gotor-Fernandez, Vicente; Gotor, Vicente
Tetrahedron, 2014 , vol. 70, # 13 p. 2264 - 2271
反应条件
hydrogenchloride 1.) H2O, pyridine, 60 deg C, 1 h, 2.) glacial AcOH, reflux, 0.5 h; Multistep reaction;
参考文献
Groutas, William C.; Kuang, Rongze; Ruan, Sumei; Epp, Jeffrey B.; Venkataraman, Radhika; Truong, Tien M.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 6 p. 661 - 671
反应条件
hydrogenchloride in water 1 h; Reflux;
参考文献
Da Silva, Marcos Reinaldo; De Mattos, Marcos Carlos; De Oliveira, Maria Da Conceicao Ferreira; De Lemos, Telma Leda Gomes; Ricardo, Nagila Maria Pontes Silva; De Gonzalo, Gonzalo; Lavandera, Ivan; Gotor-Fernandez, Vicente; Gotor, Vicente
Tetrahedron, 2014 , vol. 70, # 13 p. 2264 - 2271
