5-氯-1,2,4-噻唑并[4,3-a]吡啶合成路线 （共 5 条）
反应条件
1: 4 h; Heating / reflux; 2: With trichlorophosphate Heating / reflux; 3: With sodium hydroxide in water pH=6;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2008/118718 A2, 2008 ;
Location in patent: Page/Page column 119 ;
反应条件
1: hydrazine hydrate / ethanol / 1 h / |Reflux 2: ethanol / 2 h / 20 °C 3: N,N-dimethyl-formamide / 3 h / |Reflux View Scheme
参考文献
Guan; Zhang; Sun; Chang; Sui
Arzneimittel-Forschung/Drug Research, 2012 , vol. 62, # 8 p. 372 - 377
反应条件
1: ethanol / 2 h / 20 °C 2: N,N-dimethyl-formamide / 3 h / |Reflux View Scheme
参考文献
Guan; Zhang; Sun; Chang; Sui
Arzneimittel-Forschung/Drug Research, 2012 , vol. 62, # 8 p. 372 - 377
反应条件
in N,N-dimethyl-formamide 3 h; Reflux;
参考文献
Guan; Zhang; Sun; Chang; Sui
Arzneimittel-Forschung/Drug Research, 2012 , vol. 62, # 8 p. 372 - 377
反应条件
in N,N-dimethyl-formamide
Reflux;
参考文献
Guan; Zhang; Sun; Chang; Sui
Arzneimittel-Forschung/Drug Research, 2012 , vol. 62, # 8 p. 372 - 377
