噻吩[2,3-C]并吡啶合成路线 （共 18 条）
参考文献
Herz; Tsai
Journal of the American Chemical Society, 1953 , vol. 75, p. 5122
参考文献
Herz; Tsai
Journal of the American Chemical Society, 1953 , vol. 75, p. 5122
参考文献
Hansch et al.
Journal of Organic Chemistry, 1958 , vol. 23, p. 1924
参考文献
Tsuchiya; Sawanishi; Enkaku; Hirai
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 6 p. 1539 - 1547
反应条件
nitric acid T=25 - 85°C;
参考文献
Klemm,L.H. et al.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 299 - 303
反应条件
1: 28 percent / AlCl3 / CH2Cl2 / Ambient temperature; overnight 2: Sodium hydride / dimethylformamide / 4 h / 0 °C 3: aq. KOH / ethanol / Heating View Scheme
参考文献
Bass, R. J.; Popp, F. D.; Kant, J.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1119 - 1120
反应条件
1: aq. HNO3 / 25 - 85 °C 2: Fe / acetic acid / 1.5 h / 100 °C View Scheme
参考文献
Klemm,L.H. et al.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 299 - 303
反应条件
1: 84 percent / aluminum chloride / CH2Cl2 / 3 h / 30 °C
2: sodium hydride / dimethylformamide / 4 h / -10 °C
3: aq. NaOH / ethanol / Heating
View Scheme
参考文献
Graulich, Amaury; Scuvee-Moreau, Jacqueline; Seutin, Vincent; Liegeois, Jean-Francois
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 4972 - 4982
