噻吩并[3,2-c]吡啶合成路线 （共 27 条）
反应条件
potassium carbonate in dichloromethane; water
参考文献
Parcor
Patent: US4065459 A1, 1977 ;
反应条件
hydrogenchloride in 1,4-dioxane Heating / reflux;
参考文献
Nagarathnam, Dhanapalan; Khire, Uday; Asgari, Davoud; Shao, Jianxing; Liu, Xiao-Gao; Wang, Chunguang; Hart, Barry; Weber, Olaf; Lynch, Mark; Zhang, Lei; Wang, Lei
Patent: US2004/14755 A1, 2004 ;
Location in patent: Page/Page column 76-77 ;
US 20040014755 A1
参考文献
Hibino, Satoshi; Kano, Shinzo; Mochizuki, Naoki; Sugino, Eiichi
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 5006 - 5008
反应条件
1,4-diaza-bicyclo[2.2.2]octane in N,N-dimethyl-formamide T=120°C;
参考文献
Maffrand,J.-P.; Boigegrain,R.
Heterocycles, 1979 , vol. 12, # 11 p. 1479 - 1482
反应条件
1: 16 h / 20 - 25 °C 2: H2 / 5percent Pd/C / ethanol / 12 h / 3102.9 Torr 3: 91 percent / Et3N / ethyl acetate / 12 h / 15 - 20 °C 4: 49 percent / conc. HCl / dioxane / 16 h / Heating View Scheme
参考文献
Wikel, James H.; Denney, Michael L.; Vasileff, Robert T.
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 1 p. 289 - 290
反应条件
1: H2 / 5percent Pd/C / ethanol / 12 h / 3102.9 Torr 2: 91 percent / Et3N / ethyl acetate / 12 h / 15 - 20 °C 3: 49 percent / conc. HCl / dioxane / 16 h / Heating View Scheme
参考文献
Wikel, James H.; Denney, Michael L.; Vasileff, Robert T.
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 1 p. 289 - 290
反应条件
copper in quinoline T=205°C; 1 h;
参考文献
Farnier,M. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1066 - 1073
反应条件
1: 77 percent / n-BuLi / tetrahydrofuran / 1) ice bath, 2) r.t, overnight 2: 72 percent / 1.) KHSO4, 2.) H2O / acetone / 4.5 h / 60 °C 3: 65 percent / NH2OH*HCl, NaOAc / ethanol / 2 h / Heating 4: 70 percent / decahydronaphthalene / 200 °C View Scheme
参考文献
Hibino, Satoshi; Kano, Shinzo; Mochizuki, Naoki; Sugino, Eiichi
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 5006 - 5008
反应条件
1: 65 percent / NH2OH*HCl, NaOAc / ethanol / 2 h / Heating 2: 70 percent / decahydronaphthalene / 200 °C View Scheme
参考文献
Hibino, Satoshi; Kano, Shinzo; Mochizuki, Naoki; Sugino, Eiichi
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 5006 - 5008
反应条件
1: 72 percent / 1.) KHSO4, 2.) H2O / acetone / 4.5 h / 60 °C 2: 65 percent / NH2OH*HCl, NaOAc / ethanol / 2 h / Heating 3: 70 percent / decahydronaphthalene / 200 °C View Scheme
参考文献
Hibino, Satoshi; Kano, Shinzo; Mochizuki, Naoki; Sugino, Eiichi
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 5006 - 5008
