噻吩并[3,2-c]吡啶合成路线 （共 27 条）
反应条件
1: 91 percent / Et3N / ethyl acetate / 12 h / 15 - 20 °C 2: 49 percent / conc. HCl / dioxane / 16 h / Heating View Scheme
参考文献
Wikel, James H.; Denney, Michael L.; Vasileff, Robert T.
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 1 p. 289 - 290
反应条件
1: NBS / CHCl3 2: Ac2O / Heating 3: DABCO / dimethylformamide / 120 °C View Scheme
参考文献
Maffrand,J.-P.; Boigegrain,R.
Heterocycles, 1979 , vol. 12, # 11 p. 1479 - 1482
反应条件
1: Ac2O / Heating 2: DABCO / dimethylformamide / 120 °C View Scheme
参考文献
Maffrand,J.-P.; Boigegrain,R.
Heterocycles, 1979 , vol. 12, # 11 p. 1479 - 1482
反应条件
1: aq. KOH / 4 h / Heating 2: Cu / quinoline / 1 h / 205 °C View Scheme
参考文献
Farnier,M. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1066 - 1073
反应条件
aluminium trichloride in dichloromethane 1 h; Ambient temperature;
参考文献
New; Jass; Barrett
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 2 p. 545 - 548
反应条件
dipotassium hydrogenphosphate; bromine; sodium hydrogencarbonate; magnesium sulfate in chloroform Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/107784 A1, 2006 ;
Location in patent: Page/Page column 92 ;
WO 2006/107784 A1
反应条件
diisopropylamine in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water; acetone
参考文献
Eli Lilly and Company
Patent: US4501739 A1, 1985 ;
反应条件
dihydrogen peroxide in acetic acid
T=55°C; 24 h;
参考文献
Klemm, L. H.; Muchiri, Daniel R.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 213 - 217
反应条件
1: 67 percent / 30percent H2O2 / acetic acid / 24 h / 55 °C
2: 84 percent / benzoyl chloride / CH2Cl2; H2O
View Scheme
参考文献
Klemm, L. H.; Muchiri, Daniel R.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 213 - 217
反应条件
hydrogenchloride; n-butyllithium; lithium diisopropyl amide in tetrahydrofuran; hexane
参考文献
Eli Lilly and Company
Patent: US4480098 A1, 1984 ;
