N-(1-氰基-2,3-二氢-1H-茚-5-基)乙酰胺合成路线 （共 4 条）
反应条件
sodium methylate in methanol; ethylene glycol dimethyl ether T=20°C; Cooling with ice;
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;
Location in patent: Page/Page column 34 ;
反应条件
1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C 2: acetic anhydride; chromium(VI) oxide / water; acetic acid / 10 °C 3: sodium methylate / methanol; ethylene glycol dimethyl ether / 20 °C / |Cooling with ice View Scheme
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;
反应条件
1: acetic anhydride; chromium(VI) oxide / water; acetic acid / 10 °C 2: sodium methylate / methanol; ethylene glycol dimethyl ether / 20 °C / |Cooling with ice View Scheme
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;
反应条件
hydrogenchloride; water
48 h; Reflux;
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;
Location in patent: Page/Page column 34 ;
