8-氯-3,10-二溴-5,6-二氢-11H-苯并[5,6]环庚烷并[1,2-B]吡啶合成路线 （共 4 条）
反应条件
sulfuric acid; hypophosphorous ether; sodium nitrite in methanol; water T=-5 - 65°C; pH=9; 12 h;
参考文献
Schering Corporation
Patent: WO2004/31153 A2, 2004 ;
Location in patent: Page 19; 22; 26 ;
反应条件
acetic anhydride; trifluoroacetic acid; zinc in tetrahydrofuran T=-25 - 18°C; 24 h;
参考文献
Kuo, Shen-Chun; Chen, Frank; Hou, Donald; Kim-Meade, Agnes; Bernard, Charles; Liu, Jinchu; Levy, Stacy; Wu, George G.
Journal of Organic Chemistry, 2003 , vol. 68, # 12 p. 4984 - 4987
反应条件
1: With sulfuric acid; nitric acid T=35°C; 2 h; Inert atmosphere; 2: With ammonium hydroxide in water Inert atmosphere; Further stages;
参考文献
Wu, George G.; Chen, Frank X.; LaFrance, Danny; Liu, Zhijian; Greene, Scott G.; Wong, Yee-Shing; Xie, Ji
Organic Letters, 2011 , vol. 13, # 19 p. 5220 - 5223
反应条件
1.1: lithium diisopropylamide*THF; quinine; water / toluene; cyclohexane / 21 h / 5 - 25 °C 1.2: 10.5 g / sulfuric acid / toluene / 4 h / 85 °C 2.1: 80 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide; toluene / 18 h / 20 °C 3.1: hydrochloric acid / ethanol / 6 h / 20 °C 4.1: 5.44 g / NaOH / ethanol; 1-methyl-pyrrolidin-2-one / 10 h / 110 °C / pH 9 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 12 p. 4984 - 4987
