1,3-二甲氧基吖啶-9(10H)-酮合成路线 （共 8 条）
反应条件
1: K2CO3 / copper / 3-methyl-butan-1-ol / 10 h / 160 °C 2: H3PO4; P2O5 / 3 h / 110 °C View Scheme
参考文献
Boumendjel, Ahcene; Macalou, Sira; Ahmed-Belkacem, Abdelhakim; Blanc, Madeleine; Di Pietro, Attilio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 8 p. 2892 - 2897
反应条件
1: K2CO3 / copper / 3-methyl-butan-1-ol / 10 h / 160 °C 2: H3PO4; P2O5 / 3 h / 110 °C View Scheme
参考文献
Boumendjel, Ahcene; Macalou, Sira; Ahmed-Belkacem, Abdelhakim; Blanc, Madeleine; Di Pietro, Attilio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 8 p. 2892 - 2897
反应条件
phosphoric acid; phosphorus pentoxide T=110°C; 3 h;
参考文献
Boumendjel, Ahcene; Macalou, Sira; Ahmed-Belkacem, Abdelhakim; Blanc, Madeleine; Di Pietro, Attilio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 8 p. 2892 - 2897
反应条件
tetraethylammonium hydroxide in tetrahydrofuran; methanol Heating;
参考文献
Horne, Stephen; Rodrigo, Russell
Journal of the Chemical Society, Chemical Communications, 1991 , # 15 p. 1046 - 1048
反应条件
1: 80 percent Turnov. / NaH / -78 - 25 °C 2: 94 percent / n-BuLi / tetrahydrofuran; diethyl ether; hexane / 0.25 h / -100 - -70 °C 3: Et4NOH / tetrahydrofuran; methanol / Heating View Scheme
参考文献
Horne, Stephen; Rodrigo, Russell
Journal of the Chemical Society, Chemical Communications, 1991 , # 15 p. 1046 - 1048
反应条件
1: 94 percent / n-BuLi / tetrahydrofuran; diethyl ether; hexane / 0.25 h / -100 - -70 °C 2: Et4NOH / tetrahydrofuran; methanol / Heating View Scheme
参考文献
Horne, Stephen; Rodrigo, Russell
Journal of the Chemical Society, Chemical Communications, 1991 , # 15 p. 1046 - 1048
反应条件
hydrogenchloride; water
参考文献
Oh; Greco
Journal of Heterocyclic Chemistry, 1970 , vol. 7, p. 261,263, 266
反应条件
aluminium trichloride in acetonitrile
T=110°C; 14 h;
参考文献
Boumendjel, Ahcene; Macalou, Sira; Ahmed-Belkacem, Abdelhakim; Blanc, Madeleine; Di Pietro, Attilio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 8 p. 2892 - 2897
