1,2,4-苯并噻嗪-3-胺,7-甲氧基-,1-氧化物合成路线 （共 8 条）
参考文献
Chopra, Sidharth; Koolpe, Gary A.; Tambo-Ong, Arlyn A.; Matsuyama, Karen N.; Ryan, Kenneth J.; Tran, Tran B.; Doppalapudi, Rupa S.; Riccio, Edward S.; Iyer, Lalitha V.; Green, Carol E.; Wan, Baojie; Franzblau, Scott G.; Madrid, Peter B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6047 - 6060
反应条件
sodium hydroxide T=100°C; 1 h;
参考文献
Hay, Michael P.; Gamage, Swarna A.; Kovacs, Mary S.; Pruijn, Frederik B.; Anderson, Robert F.; Patterson, Adam V.; Wilson, William R.; Brown, J. Martin; Denny, William A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 169 - 182
反应条件
1: HCl / 100 °C 2: aq. NaOH / 1 h / 100 °C View Scheme
参考文献
Hay, Michael P.; Gamage, Swarna A.; Kovacs, Mary S.; Pruijn, Frederik B.; Anderson, Robert F.; Patterson, Adam V.; Wilson, William R.; Brown, J. Martin; Denny, William A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 169 - 182
反应条件
1.1: hydrogenchloride / water / Reflux 2.1: diethyl ether / 1 h / 100 °C 2.2: 3 h / 50 - 110 °C 2.3: 3 h / 50 - 110 °C View Scheme
参考文献
Chopra, Sidharth; Koolpe, Gary A.; Tambo-Ong, Arlyn A.; Matsuyama, Karen N.; Ryan, Kenneth J.; Tran, Tran B.; Doppalapudi, Rupa S.; Riccio, Edward S.; Iyer, Lalitha V.; Green, Carol E.; Wan, Baojie; Franzblau, Scott G.; Madrid, Peter B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6047 - 6060
反应条件
1.1: nitric acid; acetic anhydride / dichloromethane 2.1: hydrogenchloride / water / Reflux 3.1: diethyl ether / 1 h / 100 °C 3.2: 3 h / 50 - 110 °C 3.3: 3 h / 50 - 110 °C View Scheme
参考文献
Chopra, Sidharth; Koolpe, Gary A.; Tambo-Ong, Arlyn A.; Matsuyama, Karen N.; Ryan, Kenneth J.; Tran, Tran B.; Doppalapudi, Rupa S.; Riccio, Edward S.; Iyer, Lalitha V.; Green, Carol E.; Wan, Baojie; Franzblau, Scott G.; Madrid, Peter B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6047 - 6060
反应条件
1.1: triethylamine / dichloromethane 2.1: nitric acid; acetic anhydride / dichloromethane 3.1: hydrogenchloride / water / Reflux 4.1: diethyl ether / 1 h / 100 °C 4.2: 3 h / 50 - 110 °C 4.3: 3 h / 50 - 110 °C View Scheme
参考文献
Chopra, Sidharth; Koolpe, Gary A.; Tambo-Ong, Arlyn A.; Matsuyama, Karen N.; Ryan, Kenneth J.; Tran, Tran B.; Doppalapudi, Rupa S.; Riccio, Edward S.; Iyer, Lalitha V.; Green, Carol E.; Wan, Baojie; Franzblau, Scott G.; Madrid, Peter B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6047 - 6060
反应条件
phosphorus; iodine; acetic acid
参考文献
Merck and Co.Inc.
Patent: US2489351 , 1946 ;
反应条件
1: hydrogenchloride; trifluoroacetic acid; sodium nitrite / water / 1 h / 20 °C
2: trichlorophosphate / 3 h / Reflux
3: triethylamine / dichloromethane / 20 °C
View Scheme
参考文献
Chopra, Sidharth; Koolpe, Gary A.; Tambo-Ong, Arlyn A.; Matsuyama, Karen N.; Ryan, Kenneth J.; Tran, Tran B.; Doppalapudi, Rupa S.; Riccio, Edward S.; Iyer, Lalitha V.; Green, Carol E.; Wan, Baojie; Franzblau, Scott G.; Madrid, Peter B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6047 - 6060
