1: diethyl ether / -10 °C 2: PBr3 / beim nachfolgenden Kochen des Bromderivats mit alkoh.KOH und Hydrieren an Platinoxyd in Aethanol bei 2-3 at View Scheme

1: H2 / Ni 2: NaOH / methanol View Scheme

1: (i) NaOEt, DMF, (ii) /BRN= 635680/ 2: H2 / Ni 3: NaOH / methanol View Scheme

1.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0.08 h / 0 - 20 °C / |Inert atmosphere 2.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 - 20 °C / |Inert atmosphere 2.2: 0 °C 3.1: triethylamine / dichloromethane / 0.25 h / -10 °C / |Inert atmosphere 4.1: tetrahydrofuran; dimethyl sulfoxide / 24 h / 85 °C / |Inert atmosphere 5.1: sodium hydroxide; water / ethanol / 48 h / |Inert atmosphere; |Reflux View Scheme

1.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 - 20 °C / |Inert atmosphere 1.2: 0 °C 2.1: triethylamine / dichloromethane / 0.25 h / -10 °C / |Inert atmosphere 3.1: tetrahydrofuran; dimethyl sulfoxide / 24 h / 85 °C / |Inert atmosphere 4.1: sodium hydroxide; water / ethanol / 48 h / |Inert atmosphere; |Reflux View Scheme

1.1: tetrahydrofuran / 20 h / -78 - 20 °C / |Inert atmosphere 1.2: 0 °C 2.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0.08 h / 0 - 20 °C / |Inert atmosphere 3.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 - 20 °C / |Inert atmosphere 3.2: 0 °C 4.1: triethylamine / dichloromethane / 0.25 h / -10 °C / |Inert atmosphere 5.1: tetrahydrofuran; dimethyl sulfoxide / 24 h / 85 °C / |Inert atmosphere 6.1: sodium hydroxide; water / ethanol / 48 h / |Inert atmosphere; |Reflux View Scheme

sodium hydroxide in methanol

hydroxide; hydrazine

methanol; sodium Electrolysis.und anschliessend Hydrolyse;

methanol; sodium Electrolysis.und anschliessend Hydrolyse;