7-苯乙酰胺基-3-甲基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸合成路线 （共 10 条）
反应条件
1: With N,N'-bis-(trimethylsilyl)-urea in toluene T=60 - 70°C; 1 h; Large scale; 2: With pyridin-2-yl hydrobromide in toluene T=70 - 80°C; Large scale; Concentration;
参考文献
Salehpour, Pooneh; Yegani, Reza; Hajmohammadi, Reza
Organic Process Research and Development, 2012 , vol. 16, # 9 p. 1507 - 1512
反应条件
tetrakis(triphenylphosphine) palladium(0); 2-ethyl-hexanoic acid potassium salt; triphenylphosphine in dichloromethane; ethyl acetate 1 h; Ambient temperature;
参考文献
Jeffrey, Paul D.; McCombie, Stuart W.
Journal of Organic Chemistry, 1982 , vol. 47, # 3 p. 587 - 590
反应条件
1: 94 percent / sodium iodide / dimethylformamide / 20 h / 25 °C 2: m-chloroperbenzoic acid (MCPBA) / CH2Cl2 3: 54 percent / 85percent phosphoric acid, pyridine / dioxane / 5 h / Heating 4: 54 percent / potassium 2-ethylhexanoate, tetrakis(triphenylphosphine)palladium, PPh3 / CH2Cl2; ethyl acetate / 1 h / Ambient temperature View Scheme
参考文献
Jeffrey, Paul D.; McCombie, Stuart W.
Journal of Organic Chemistry, 1982 , vol. 47, # 3 p. 587 - 590
反应条件
1: m-chloroperbenzoic acid (MCPBA) / CH2Cl2 2: 54 percent / 85percent phosphoric acid, pyridine / dioxane / 5 h / Heating 3: 54 percent / potassium 2-ethylhexanoate, tetrakis(triphenylphosphine)palladium, PPh3 / CH2Cl2; ethyl acetate / 1 h / Ambient temperature View Scheme
参考文献
Jeffrey, Paul D.; McCombie, Stuart W.
Journal of Organic Chemistry, 1982 , vol. 47, # 3 p. 587 - 590
反应条件
1: 54 percent / 85percent phosphoric acid, pyridine / dioxane / 5 h / Heating 2: 54 percent / potassium 2-ethylhexanoate, tetrakis(triphenylphosphine)palladium, PPh3 / CH2Cl2; ethyl acetate / 1 h / Ambient temperature View Scheme
参考文献
Jeffrey, Paul D.; McCombie, Stuart W.
Journal of Organic Chemistry, 1982 , vol. 47, # 3 p. 587 - 590
反应条件
1: 94 percent / potassium 2-ethylhexanoate, tetrakis(triphenylphosphine)palladium, PPh3 / ethyl acetate / 2 h / 25 °C 2: 94 percent / sodium iodide / dimethylformamide / 20 h / 25 °C 3: m-chloroperbenzoic acid (MCPBA) / CH2Cl2 4: 54 percent / 85percent phosphoric acid, pyridine / dioxane / 5 h / Heating 5: 54 percent / potassium 2-ethylhexanoate, tetrakis(triphenylphosphine)palladium, PPh3 / CH2Cl2; ethyl acetate / 1 h / Ambient temperature View Scheme
参考文献
Jeffrey, Paul D.; McCombie, Stuart W.
Journal of Organic Chemistry, 1982 , vol. 47, # 3 p. 587 - 590
反应条件
pyridine; chloro-trimethyl-silane Rearrangement; 24 h;
参考文献
Chae, Hyungsun; Cho, Sangwon; Keum, Gyochang; Kang, Soon Bang; Pae, Ae Nim; Kim, Youseung
Tetrahedron Letters, 2000 , vol. 41, # 20 p. 3899 - 3901
反应条件
(i) Ts, THF, H2O, (ii) MnO2, aq. AcOH; Multistep reaction;
参考文献
de Oliveira Baptista; Barrett; Barton; Girijavallabhan; Jennings; Kelly; Papadimitriou; Turner; Usher
Journal of the Chemical Society. Perkin transactions 1, 1977 , # 12 p. 1477 - 1500
反应条件
potassium hydroxide; acetic acid n-butyl ester; penicillin acylase from E. coli in water T=20°C; pH=3.4; Enzymatic reaction; Kinetics; Further Variations:pH-values;
参考文献
Chilov, Ghermes G.; Svedas, Vytas K.
Canadian Journal of Chemistry, 2002 , vol. 80, # 6 p. 699 - 707
反应条件
potassium hydroxide; acetic acid n-butyl ester; penicillin acylase from E. coli in water T=20°C; pH=3.4; Enzymatic reaction; Kinetics; Further Variations:pH-values;
参考文献
Chilov, Ghermes G.; Svedas, Vytas K.
Canadian Journal of Chemistry, 2002 , vol. 80, # 6 p. 699 - 707
