(S)-N-(2,6-二甲苯及)哌啶-2-甲酰胺合成路线 （共 25 条）
反应条件
1: 88 percent / Et3N / H2O; acetone 2: 1) N-methylmorpholine, isobutyl chloroformate / 1) THF, 0 deg C to 5 deg C, 2) THF, r.t. 3: HCl / CH2Cl2 / 0 - 5 °C View Scheme
参考文献
Ho, Bin; Venkatarangan, Prabha M.; Cruse, Sharon F.; Hinko, Christine N.; Andersen, Peter H.; Crider, Albert M.; Adloo, Ahmad A.; Roane, David S.; Stables, James P.
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 1 p. 23 - 31
反应条件
1: sodium carbonate / 1 h / 20 °C 2: sodium hydroxide / water / 36 h / |Reflux 3: ethanol / 15 - 50 °C 4: sodium carbonate / 2 h / 20 °C View Scheme
参考文献
NEON LABORATORIES LIMITED; DALVI, Mahesh Bhagoji; KENNY, Rajesh Shashikant; TARADE, Pradeep Kisan
Patent: WO2014/9964 A1, 2014 ;
反应条件
in tetrahydrofuran 20 - 24 h; Heating / reflux;
参考文献
L. MOLTENI and C. DEI FRATELLI ALITTI - SOCIETA DI ESERCIZIO S.P.A.
Patent: WO2006/133837 A2, 2006 ;
Location in patent: Page/Page column 3-4 ;
反应条件
Shvo catalyst in anhydrous butyl ether T=140°C; 1 h; Inert atmosphere;
参考文献
Von Langermann, Jan; Kaspereit, Malte; Shakeri, Mozaffar; Lorenz, Heike; Hedberg, Martin; Jones, Matthew J.; Larson, Kerstin; Herschend, Bjoern; Arnell, Robert; Temmel, Erik; Baeckvall, Jan-Erling; Kienle, Achim; Seidel-Morgenstern, Andreas
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 343 - 352
反应条件
Shvo catalyst in anhydrous butyl ether T=140°C; 2 h; Inert atmosphere;
参考文献
Von Langermann, Jan; Kaspereit, Malte; Shakeri, Mozaffar; Lorenz, Heike; Hedberg, Martin; Jones, Matthew J.; Larson, Kerstin; Herschend, Bjoern; Arnell, Robert; Temmel, Erik; Baeckvall, Jan-Erling; Kienle, Achim; Seidel-Morgenstern, Andreas
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 343 - 352
