3-[(2R,5S)-5-(4-氟苯基)-2-[(S)-[(4-氟苯基(氨基)]][4-(三甲基硅)氧]苯基]甲基]-1-氧代-5-[(三甲基硅)氧]苯基]-4-苯基-(4S)-2-恶唑烷酮合成路线 （共 2 条）
反应条件
1: (E)-(4-hydroxy-benzylidene)-(4-fluorophenyl)-amine; (S)-3-[5-(4-fluorophenyl)-5(S)-hydroxy-pentanoyl]-4-phenyl-oxazolidin-2-one With N-ethyl-N,N-diisopropylamine in dichloromethane T=-10 - -5°C; 2: chloro-trimethyl-silane in dichloromethane T=-5°C; 1.5 h; 3: With titanium tetrachloride in dichloromethane T=-30 - -25°C; 3 h;
参考文献
US2006/135755 A1, ;
Page/Page column 16-17 ;
反应条件
1: chloro-trimethyl-silane; 4-fluoro-N-(4-hydroxyphenyl)methylene-benzenamine; (S)-3-[5-(4-fluorophenyl)-5(S)-hydroxy-pentanoyl]-4-phenyl-oxazolidin-2-one With N-ethyl-N,N-diisopropylamine in dichloromethane T=-10 - -5°C; 1 h; 2: With titanium tetrachloride in dichloromethane T=-30°C; 20 h; 3: N,O-bis-(trimethylsilyl)-acetamide
参考文献
WO2012/4382 A1, ;
Page/Page column 25 ;
