N,N-二乙基-2-甲基苯甲酰胺合成路线 （共 30 条）
反应条件
1: n-butyllithium / tetrahydrofuran; hexane / -78 - -60 °C / |Inert atmosphere; |Sealed tube 2: hydrogenchloride / tetrahydrofuran / 1 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron Letters, , vol. 55, # 7 p. 1366 - 1369
反应条件
hydrogenchloride; N,N,N',N'-tetraethyl ethylenediamine; sec.-butyllithium other substituted ortho-toluamides (also ortho toluates), vinysilanes, and lithiating reagents;
参考文献
Date; Watanabe; Furukawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 4 p. 902 - 906
反应条件
Yield given. Multistep reaction;
参考文献
Date; Watanabe; Furukawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 4 p. 902 - 906
反应条件
Yield given. Multistep reaction;
参考文献
Date; Watanabe; Furukawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 4 p. 902 - 906
反应条件
1: With disodium hydrogenphosphate in acetonitrile T=20°C; Methylation; 2: With sodium hydrogencarbonate Hydrolysis; 18 h;
参考文献
Keck, Gary E; McLaws, Mark D; Wager, Travis T
Tetrahedron, 2000 , vol. 56, # 51 p. 9875 - 9883
反应条件
1.1: LDA / tetrahydrofuran; hexane / -78 - 0 °C 1.2: 58 percent / tetrahydrofuran; hexane / 2 h / -78 °C 2.1: 48 percent / MeSO2Cl; BF3*OEt2 / 2 h / 70 °C 3.1: 49 percent / LDA / tetrahydrofuran; hexane / 2 h / -78 °C View Scheme
参考文献
Thasana, Nopporm; Ruchirawat, Somsak
Synlett, 2003 , # 7 p. 1037 - 1039
反应条件
Yield given. Multistep reaction;
参考文献
Julia, Marc
Bulletin de la Societe Chimique de France, 1996 , vol. 133, # 1 p. 15 - 24
反应条件
1: 1.) LDA / 1.) THF, hexane, -70 deg C 2.) THF, hexane, -70 deg C, 10 min
2: 83 percent / p-toluenosulfonic acid / xylene / 48 h
View Scheme
参考文献
Clark, Robin D.; Jahangir
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5378 - 5382
反应条件
1: 1.) LDA / THF, 1.) -78 deg C , 1 h , 2.) -78 deg C to room temperature , 8 h
2: 50percent NaOH / H2O; ethanol / 8 h / Heating
View Scheme
参考文献
Watanabe, Mitsuaki; Sahara, Masanori; Kubo, Masaki; Furukawa, Sunao; Billedeau, R. J.; Snieckus, V.
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 742 - 747
反应条件
1: 1.) tert-BuLi, TMEDA / 1.) -70 deg C
2: 91 percent / acetic acid / 3 h / Heating
View Scheme
参考文献
Ohta; Kamata; Inagaki; Masuda; Yamamoto; Yamashita; Kawasaki
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 6 p. 1188 - 1190
