(R)-(+)-1-(4-氯苯基)乙胺合成路线 （共 14 条）
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 24 h / Cooling with ice 1.2: 20 °C 2.1: C9H16BNO / tetrahydrofuran / 24 h / 20 °C 2.2: 24 h / Reflux View Scheme
参考文献
Pakulski, Marcin M.; Mahato, Sanjit K.; Bosiak, Mariusz J.; Krzeminski, Marek P.; Zaidlewicz, Marek
Tetrahedron Asymmetry, 2012 , vol. 23, # 9 p. 716 - 721
反应条件
1.1: hydroxylamine hydrochloride / water; methanol / 25 °C 2.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 3.2: 18 h / 20 °C 4.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
1.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 2.2: 18 h / 20 °C 3.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
sodium hydrogencarbonate in dichloromethane
3 h;
参考文献
Manjula; Malleshappa Noolvi; Vipan Parihar; Manohara Reddy; Ramani, Vijay; Gadad, Andanappa K.; Singh, Gurdial; Gopalan Kutty; Mallikarjuna Rao
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2923 - 2929
