(7S)-7-氨基-1,2,3-三甲氧基-10-甲硫基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮合成路线 （共 15 条）
反应条件
hydrogenchloride in methanol T=90°C; 96 h;
参考文献
Lee, Sun-Hee; Park, Sun-Kyoung; Kim, Jeong-Mi; Kim, Myung-Hwa; Kim, Kwang-Hee; Chun, Kwang-Woo; Cho, Kyung-Hea; Youn, Ji-Youn; Namgoong, Sung Keon
Archiv der Pharmazie, 2005 , vol. 338, # 12 p. 582 - 589
反应条件
1: 63 percent / H2O / 96 h 2: 66 percent / HCl / methanol / 96 h / 90 °C View Scheme
参考文献
Chang, Dong-Jo; Kim, Wan-Joo
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 14 p. 3121 - 3125
反应条件
hydrogenchloride T=90°C; 72 h;
参考文献
Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282
反应条件
1: 71 percent / methanol; dimethylformamide / Ambient temperature 2: 89 percent / 2N aq. HCl / methanol / 60 h / 85 - 90 °C 3: 22 percent / pyridine / Ambient temperature 4: 10 percent / 20percent methanol. HCl / 72 h / 90 °C View Scheme
参考文献
Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282
反应条件
1: 89 percent / 2N aq. HCl / methanol / 60 h / 85 - 90 °C 2: 22 percent / pyridine / Ambient temperature 3: 10 percent / 20percent methanol. HCl / 72 h / 90 °C View Scheme
参考文献
Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282
反应条件
1: 22 percent / pyridine / Ambient temperature 2: 10 percent / 20percent methanol. HCl / 72 h / 90 °C View Scheme
参考文献
Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282
反应条件
1: 22 percent / pyridine / Ambient temperature 2: 10 percent / 20percent methanol. HCl / 72 h / 90 °C View Scheme
参考文献
Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282
反应条件
pyridine 4 h; Ambient temperature;
参考文献
Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282
反应条件
1: 22 percent / pyridine / Ambient temperature 2: 10 percent / 20percent methanol. HCl / 72 h / 90 °C 3: 93.5 percent / pyridine / 4 h / Ambient temperature View Scheme
参考文献
Shi, Qian; Verdier-Pinard, Pascal; Brossi, Arnold; Hamel, Ernest; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2277 - 2282
反应条件
in methanol; water
T=0°C; 2 h;
参考文献
Lin, Tai-Shun; Shiau, George T.; Prusoff, William H.; Harmon, Robert E.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1440 - 1442
