1: thiophenol With sodium carbonate in water T=20°C; 0.5 h; 2: β-chloro-L-alanine With sodium carbonate in water pH=8 - 10; 5 h; 3: With hydrogenchloride in water; toluene pH=0.5;
potassium phosphate buffer; serine hydroxymethyltransferase enzyme T=30°C; 0.666667 h; inhibitory effect on the hydroxymethyltransferase enzyme at various concentrations;
sodium hydroxide in 1,4-dioxane; water 1.) 0 deg C, 15 min, 2.) RT, 2 h;
参考文献
Cheung, Kam Sing; Wasserman, Steven A.; Dudek, Edward; Lerner, Stephen A.; Johnston, Michael
Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1733 - 1741
