3,5-二苄氧基苯甲酸甲酯合成路线 （共 24 条）
反应条件
1.1: 99 percent / AcOH; 60 percent aq. HClO4 / 0.08 h / 35 °C
2.1: 97 percent / H2 / 5 percent Pd/C / ethanol
3.1: MeONa / methanol / 0.33 h / 60 °C
3.2: 20 percent / NaBH4 / methanol / 4 h / 60 °C
4.1: 76 percent / 1N NaOH / 3 h / 45 °C
View Scheme
参考文献
Ichinose; Ebizuka; Sankawa
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 2 p. 192 - 196
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in toluene
T=20°C; 1 h; Inert atmosphere;
参考文献
Resch, Verena; Lechner, Horst; Schrittwieser, Joerg H.; Wallner, Silvia; Gruber, Karl; MacHeroux, Peter; Kroutil, Wolfgang
Chemistry - A European Journal, 2012 , vol. 18, # 41 p. 13173 - 13179
反应条件
1: diethyl ether
2: 99 percent / 60percent HClO4 / H2O; acetic acid
3: 97 percent / H2 / Pd/C (5percent) / ethyl acetate; ethanol
4: CH3ONa / methanol
5: NaBH4 / methanol
View Scheme
参考文献
Ichinose, Koji; Ebizuka, Yutaka; Sankawa, Ushio
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2873 - 2875
反应条件
1: KOAc / acetic anhydride / 10 h / 150 °C
2: K2CO3 / acetone
3: LAH; AlCl3 / diethyl ether; tetrahydrofuran / 1.5 h
4: 11 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 7.5 h / Heating
5: hydrogen / Pd-C / ethanol
View Scheme
参考文献
Kinoshita, Takeshi; Ichinose, Koji
Heterocycles, 2005 , vol. 65, # 7 p. 1641 - 1654
