1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran T=20°C; 1 h; 2: 3-Oxo-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester in tetrahydrofuran T=35°C; 2 h; Product distribution / selectivity;

1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran 1 h; 2: 3-Oxo-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester in tetrahydrofuran T=20°C; 16 h;

potassium tert-butylate in tetrahydrofuran; ethyl acetate

1: With sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran T=0 - 20°C; 2: With water in tetrahydrofuran 3: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=50°C; 1 h;