4-甲基-2-硝基苯甲酸合成路线 （共 20 条）
反应条件
1: lithium methanoate With acetic anhydride; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 1 h; 2: 2-nitro-4-methyliodobenzene With tris(dibenzylideneacetone)dipalladium (0); lithium chloride in N,N-dimethyl-formamide T=80°C; 7 h;
参考文献
Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella
Organic Letters, 2003 , vol. 5, # 23 p. 4269 - 4272
反应条件
sulfuric acid; acetic acid
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5389641 A1, 1995 ;
US 5389641 A
反应条件
CuCN in aq H2 SO4; benzonitrile; N,N-dimethyl-formamide
参考文献
Rohm and Haas Company
Patent: US4781750 A1, 1988 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane 2 h; Heating;
参考文献
Herbert, John M.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 817 - 819
反应条件
hydrogenchloride im Druckrohr;
参考文献
Archer; Suter
Journal of the American Chemical Society, 1952 , vol. 74, p. 4296,4301
反应条件
1: in N,N-dimethyl-formamide 2: With sulfuric acid in water
参考文献
Matsui, Toshiaki; Takahashi, Shinya; Matsunaga, Naoki; Nakamura, Kazunori; Omawari, Nagashige; Sakai, Masaru; Kamoshima, Wataru; Terai, Kouichiro; Ohno, Hiroyuki; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 12 p. 3807 - 3815
反应条件
Erhitzen des Reaktionsprodukts mit wss. Salpetersaeure;
参考文献
Yen
Chlorine Alkali NewsChem.Abstr., 1953 , # 11 p. 44
Chlorine Alkali NewsChem.Abstr., 1955 , p. 7523
反应条件
1: tin; hydrochloric acid 2: durch Austausch der NH2-Gruppe durch OH auf dem Wege der Diazotierung View Scheme
参考文献
Niementowski; Rozanski
Chemische Berichte, 1888 , vol. 21, p. 1998
反应条件
1.1: diphenylphosphoryl chloride; Et3N / CHCl3 1.2: NH3 2.1: H2 / 5 percent Pd/C / ethanol View Scheme
参考文献
Glenmark Pharmaceuticals S.A.; GHARAT, Laxmikant Atmaram; Banerjee, Abhisek; Khairatkar-Joshi, Neelima; Kattige, Vidya Ganapati
Patent: US2013/210844 A1, 2013 ;
反应条件
triphenylphosphine; silver carbonate; palladium dichloride in dimethyl sulfoxide T=130°C; 6 h; Inert atmosphere;
参考文献
Xie, Kai; Wang, Sizhuo; Yang, Zhiyong; Liu, Jidan; Wang, Anwei; Li, Xiujian; Tan, Ze; Guo, Can-Cheng; Deng, Wei
European Journal of Organic Chemistry, 2011 , # 29 p. 5787 - 5790
