3-氨基-5-氯吡啶甲酸乙酯合成路线 （共 6 条）
反应条件
1: 64 percent / nitric acid; conc. sulfuric acid / 55 - 57 °C
2: 52 percent / NaNO2; conc. HBr; Br2 / 0 °C
3: 80 percent / 150 °C
4: 95 percent / H2 / Raney nickel / aq. ethanol / 2.5 h / 2327.17 Torr
5: 85 percent / conc. HCl / 17 h / Heating
6: 87 percent / conc. H2SO4 / 12 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
反应条件
1: 80 percent / 150 °C
2: 95 percent / H2 / Raney nickel / aq. ethanol / 2.5 h / 2327.17 Torr
3: 85 percent / conc. HCl / 17 h / Heating
4: 87 percent / conc. H2SO4 / 12 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
反应条件
1: 95 percent / H2 / Raney nickel / aq. ethanol / 2.5 h / 2327.17 Torr
2: 85 percent / conc. HCl / 17 h / Heating
3: 87 percent / conc. H2SO4 / 12 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
反应条件
1: 52 percent / NaNO2; conc. HBr; Br2 / 0 °C
2: 80 percent / 150 °C
3: 95 percent / H2 / Raney nickel / aq. ethanol / 2.5 h / 2327.17 Torr
4: 85 percent / conc. HCl / 17 h / Heating
5: 87 percent / conc. H2SO4 / 12 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
反应条件
sulfuric acid
12 h; Heating;
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
反应条件
1: 85 percent / conc. HCl / 17 h / Heating
2: 87 percent / conc. H2SO4 / 12 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
