2,4-二氯-5-磺酰胺基苯甲酸合成路线 （共 7 条）
参考文献
Loev,B. et al.
Journal of Medicinal Chemistry, 1974 , vol. 17, p. 956 - 965
反应条件
1: ClSO3H 2: aq. NH3 View Scheme
参考文献
Loev,B. et al.
Journal of Medicinal Chemistry, 1974 , vol. 17, p. 956 - 965
反应条件
in N,N-dimethyl-formamide T=160°C; 2 h;
参考文献
Cherkez, S.; Herzig, J.; Yellin, H.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 947 - 959
反应条件
thionyl chloride
Heating;
参考文献
Hoefle; Blouin; DeWald; Holmes; Williams
Journal of medicinal chemistry, 1968 , vol. 11, # 5 p. 970 - 973
参考文献
USV Pharmaceutical Corp.
Patent: US4596791 A1, 1986 ;
US 4596791 A
Title/Abstract Full Text Show Details
USV Pharmaceutical Corporation
Patent: US4666906 A1, 1987 ;
参考文献
Loev,B. et al.
Journal of Medicinal Chemistry, 1974 , vol. 17, p. 956 - 965
反应条件
1: 33 percent / dimethylformamide / 2 h / 160 °C
2: 34 percent / AcOH, Zn / methanol / 6 h / 45 °C
3: Zn, CuSO4*5H2O, aq. NaOH / 1 h / 90 °C
4: concd. HCl / 0.5 h / 90 °C
View Scheme
参考文献
Cherkez, S.; Herzig, J.; Yellin, H.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 947 - 959
