4-氯-1-甲基吡咯并[3,2-C]吡啶合成路线 （共 6 条）
反应条件
trichlorophosphate Heating;
参考文献
New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156
反应条件
trichlorophosphate T=100°C; 2 h; 0-10 deg C (adding);
参考文献
Robaut; Rivalle; Rautureau; et al.
Tetrahedron, 1985 , vol. 41, # 10 p. 1945 - 2951
反应条件
1: 94 percent / POCl3 / 2 h / 100 °C / 0-10 deg C (adding) 2: 74.6 percent / NaBH4 / methanol / 2 h / Ambient temperature; 0 deg C (adding) View Scheme
参考文献
Robaut; Rivalle; Rautureau; et al.
Tetrahedron, 1985 , vol. 41, # 10 p. 1945 - 2951
反应条件
(NH4)2CO3; urea T=150°C; P=20520 Torr; 24 h;
参考文献
Casy, Alan F.; Needle, Richard J.; Upton, Christopher
Journal of Chemical Research, Miniprint, 1986 , # 1 p. 343 - 360
反应条件
tert.-butyl lithium
1.) THF, -70 deg C to -65 deg C, 10 min, 2.) -65 deg C, 10 min; room temperature, 45 min; Yield given. Multistep reaction;
参考文献
Bisagni, E.; Hung, N. Chi; Lhoste, J. M.
Tetrahedron, 1983 , vol. 39, # 10 p. 1777 - 1782
反应条件
tert.-butyl lithium
1.) THF, -65 deg C, 10 min, 2.) -65 deg C, 45 min; room temperature, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bisagni, E.; Hung, N. Chi; Lhoste, J. M.
Tetrahedron, 1983 , vol. 39, # 10 p. 1777 - 1782
