1,3-苯并间二氧杂环戊烯合成路线 （共 145 条）
反应条件
n-butyllithium; sodium hydrogencarbonate in hexane
参考文献
SmithKline Beecham Corporation
Patent: US6262113 B1, 2001 ;
US 6262113 B1
反应条件
1: Methylenedioxybenzene With sec.-butyllithium in tetrahydrofuran; pentane T=-100°C; 2 h; 2: carbon dioxide in tetrahydrofuran; pentane Further stages.;
参考文献
Chemistry - A European Journal, , vol. 8, # 4 p. 799 - 804
反应条件
bromine in tetrachloromethane T=0 - 5°C;
参考文献
Lawrence, David S.; Whitten, David G.
Photochemistry and Photobiology, 1996 , vol. 64, # 6 p. 923 - 935
反应条件
1: 85 percent / Br2 / acetic acid / 1 h 2: 1.) n-BuLi / 1.) Et2O, 0 deg C 3: NaBH4 / ethanol / -22 °C View Scheme
参考文献
Keck,G.E.; Webb,R.R.
Journal of the American Chemical Society, 1981 , vol. 103, p. 3173
参考文献
Hara, Hiroshi; Satoh, Hiroya; Hoshino, Osamu
Heterocycles, 1992 , vol. 33, # 1 p. 43 - 46
反应条件
1.1: 90 percent / N-bromosuccinimide / CHCl3 / 3.5 h / Heating 2.1: n-BuLi / diethyl ether; hexane / 0.17 h / -30 °C 2.2: 80 percent / tetrahydrofuran; diethyl ether; hexane / 2 h / 20 °C View Scheme
参考文献
Magnus; Bailey; Porter
Tetrahedron, 1999 , vol. 55, # 49 p. 13927 - 13936
反应条件
[Ir2(OMe)2(1,5-cyclooctadiene)2]; 2,2'-bis(2-oxazoline) in cyclohexane T=70°C; 24 h; Inert atmosphere;
参考文献
Vanchura II, Britt A.; Preshlock, Sean M.; Roosen, Philipp C.; Kallepalli, Venkata A.; Staples, Richard J.; Maleczka Jr., Robert E.; Singleton, Daniel A.; Smith III, Milton R.
Chemical Communications, 2010 , vol. 46, # 41 p. 7724 - 7726
反应条件
1.1: 93 percent / NBS 2.1: n-BuLi / hexane; tetrahydrofuran / 0.17 h / -78 °C 2.2: hexane; tetrahydrofuran / 2.5 h / -78 - 20 °C 3.1: hexane; tetrahydrofuran / 2 h / 20 °C 3.2: glacial acetic acid / hexane; tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Steinke, Nelli; Frey, Wolfgang; Baro, Angelika; Laschat, Sabine; Drees, Christina; Nimtz, Manfred; Haegele, Constanze; Giesselmann, Frank
Chemistry - A European Journal, 2006 , vol. 12, # 4 p. 1026 - 1035
反应条件
1: chloroform; N-bromo-succinimide 2: butyl lithium; diethyl ether / -35 °C / Behandeln des Reaktionsgemisches mit festem Kohlendioxid View Scheme
参考文献
Gensler; Stouffer
Journal of Organic Chemistry, 1958 , vol. 23, p. 908
反应条件
1: 71 percent / p-toluenesulfonic acid / 1,2-dichloro-ethane / 1 h / Heating 2: 73 percent / zinc dust, acetic acid / 15 h / Heating 3: 80 percent / LiAlH4-AlCl3 / tetrahydrofuran; diethyl ether / 15 h / Ambient temperature View Scheme
参考文献
Ishibashi; Miki; Ikeda; Kiriyama
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 12 p. 3396 - 3398
