[1,2,4]三唑并[1,5-a]吡啶合成路线 （共 10 条）
反应条件
trifluoroacetic anhydride in tetrahydrofuran T=20°C;
参考文献
Huntsman, Elliott; Balsells, Jaume
European Journal of Organic Chemistry, 2005 , # 17 p. 3761 - 3765
反应条件
hydroxylamine-o-sulphonic acid in pyridine; methanol 1 h; Ambient temperature;
参考文献
Lin, Yang-i; Lang, S.A.
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3123 - 3124
反应条件
1.1: propan-2-ol / Heating 1.2: 63 percent / hydroxylamine hydrochloride / propan-2-ol / 50 °C 2.1: 77 percent / trifluoroacetic anhydride / tetrahydrofuran / 20 °C View Scheme
参考文献
Huntsman, Elliott; Balsells, Jaume
European Journal of Organic Chemistry, 2005 , # 17 p. 3761 - 3765
参考文献
Tomazic, Alenka; Tisler, Miha; Stanovnik, Branko
Tetrahedron, 1981 , vol. 37, p. 1787 - 1794
反应条件
1: 59 percent / CH2Cl2 / 1.) -5 deg C to RT, 2.) RT, 15 min 2: 61 percent / hydroxylamine / ethanol / 71 h / Ambient temperature 3: 48 percent / 196 °C View Scheme
参考文献
Tomazic, Alenka; Tisler, Miha; Stanovnik, Branko
Tetrahedron, 1981 , vol. 37, p. 1787 - 1794
反应条件
2: Heating View Scheme
参考文献
Golic, Ljubo; Stropnik, Crtomir; Stanovnik, Branko; Tisler, Miha
Heterocycles, 1987 , vol. 25, p. 347 - 358
反应条件
T=170°C; 3 h; variation of reaction conditions; Product distribution;
参考文献
Tomazic, Alenka; Tisler, Miha; Stanovnik, Branko
Tetrahedron, 1981 , vol. 37, p. 1787 - 1794
反应条件
n-butyllithium 1.) THF, hexane, -78 deg C, 30 min, 2.) -78 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Finkelstein, Bruce L.
Journal of Organic Chemistry, 1992 , vol. 57, # 20 p. 5538 - 5540
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2a.) -78 deg C, 5 min, 2b.) -78 deg C to RT; other electrophiles, regioselectivity;
参考文献
Finkelstein, Bruce L.
Journal of Organic Chemistry, 1992 , vol. 57, # 20 p. 5538 - 5540
反应条件
n-butyllithium
1.) THF, hexane, -78 deg C, 30 min, 2a.) -78 deg C, 5 min, 2b.) -78 deg C to RT; Yield given. Multistep reaction;
参考文献
Finkelstein, Bruce L.
Journal of Organic Chemistry, 1992 , vol. 57, # 20 p. 5538 - 5540
