4,6-二甲基-2-嘧啶甲醛合成路线 （共 8 条）
反应条件
n-butyllithium in diethyl ether; pentane
T=-90 - 20°C; Formylation; 1.5 h;
参考文献
Barr, Christa L.; Chase, Preston A.; Hicks, Robin G.; Lemaire, Martin T.; Stevens, Cecilia L.
Journal of Organic Chemistry, 1999 , vol. 64, # 24 p. 8893 - 8897
反应条件
selenium(IV) oxide in 1,4-dioxane
1 h; Heating;
参考文献
Sakamoto, Takao; Tanji, Ken-Ichi; Niitsuma, Setsuko; Ono, Takayasu; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3362 - 3368
反应条件
1: 93 percent / cc. H2SO4, (NH4)2S2O8 / H2O / 5 h / Heating
2: 49 percent / SeO2 / dioxane / 1 h / Heating
View Scheme
参考文献
Sakamoto, Takao; Tanji, Ken-Ichi; Niitsuma, Setsuko; Ono, Takayasu; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3362 - 3368
反应条件
hydrogenchloride in ethanol
1 h; Heating;
参考文献
Sakamoto, Takao; Tanji, Ken-Ichi; Niitsuma, Setsuko; Ono, Takayasu; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3362 - 3368
反应条件
1: 86 percent / 30 percent H2O2 / acetone / 168 h / Ambient temperature
2: 81 percent / I2 / 6 h / Heating
3: cc. HCl / aq. ethanol / 1 h / Heating
View Scheme
参考文献
Sakamoto, Takao; Tanji, Ken-Ichi; Niitsuma, Setsuko; Ono, Takayasu; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3362 - 3368
反应条件
1: 81 percent / I2 / 6 h / Heating
2: cc. HCl / aq. ethanol / 1 h / Heating
View Scheme
参考文献
Sakamoto, Takao; Tanji, Ken-Ichi; Niitsuma, Setsuko; Ono, Takayasu; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3362 - 3368
反应条件
1: 78 percent / benzyltriethylammonium chloride / benzene / 22 h / 70 °C
2: 86 percent / 30 percent H2O2 / acetone / 168 h / Ambient temperature
3: 81 percent / I2 / 6 h / Heating
4: cc. HCl / aq. ethanol / 1 h / Heating
View Scheme
参考文献
Sakamoto, Takao; Tanji, Ken-Ichi; Niitsuma, Setsuko; Ono, Takayasu; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3362 - 3368
反应条件
potassium permanganate; water
参考文献
Ochiai; Yanai
Yakugaku Zasshi, 1938 , vol. 58, p. 397,399; dtsch. Ref. S. 76, 77
Chem.Abstr., 1938 , p. 6653
